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SB-202190
SynDRA canonical compound SYN0001011 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | MAPK14 |
|---|
| Mechanism of action | P38 MAPK inhibitor |
|---|
All known targets
- MAPK14
- AKT1
- ALOX5
- CDK8
- CHEK1
- GSK3B
- LCK
- MAPK1
- MAPK11
- MAPK12
- MAPK8
- PRKCA
Mechanisms of action (all sources)
- MAPK14 INHIBITOR
- CDK8 INHIBITOR
- PTGS2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PRKACB
- BRD4
- FRK
- DDR2
- MAP2K2
- COQ8B
- GAK
- GCGR
- RIPK2
- LATS2
- ROS1
- RPS6KA1
- SYK
- CDC42BPB
- CDC42BPG
- STK36
- NLK
- STK32B
- NTRK2
- NTRK3
- RPS6KA6
- CSNK1E
- CSNK1D
- CSNK1A1L
- CIT
- IGF1R
- SLK
- BRDT
- DDR1
- BRAF
- TTBK2
- YES1
- PRKACA
- ACVR1B
- ACVR2B
- EPHA6
- MAPK13
- MAPK10
- RAF1
- TTK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACV1B
- BARD1
- MDM2
- MDM4
- MK01
- MK08
- MK09
- MK10
- MK11
- MK14
- MRCKG
- NSD2
- NTM1A
- NTMT1
- SNCA
- SYUA
- TNNC1
- TNNI3
- TNNT2
- M4K4
- KSYK
- KS6A6
- ESRRA
- BRCA1
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CTRO
- GEMI
- KS6A1
- IFNG
- KAPCA
- KAPCB
- KC1A
- KC1D
- KC1E
- KPCD3
- TP53
Drug classes
Cross-references
Synonyms
- Oxindole 94
- SB202190
- FHPI
- SB202190 (FHPI)
- UNII-PVX798P8GI
- 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
- CHEBI:79090
- 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole
- PVX798P8GI
- SB 202190, Immobilized
- C20H14FN3O
- Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-
- 4-[4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
- 4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol
- RefChem:884639
- DTXCID5021120
- MFCD00941964
- 4-[4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazol-2-yl]phenol
- 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol
- SMR001230795
- Kinome_3708
- Tocris-1264
- BiomolKI_000051
- Lopac-S-7067
- BiomolKI2_000057
- Lopac0_000173
- BMK1-F3
- BSPBio_001106
- KBioGR_000446
- KBioSS_000446
- MLS002153419
- MLS006010258
- SCHEMBL158854
- GTPL4307
- orb1305747
- SCHEMBL1230814
- SCHEMBL3386753
- BDBM13531
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