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TRIAMTERENE
SynDRA canonical compound SYN0000963 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCNN1G |
|---|
| Mechanism of action | Sodium channel blocker |
|---|
| Indication | edema | hypertension | hypokalemia |
|---|
| Disease area | cardiology | endocrinology |
|---|
All known targets
- SCNN1A
- SCNN1B
- SCNN1G
- SCNN1D
- CASP1
- CTSG
- CYP2D6
- PTR1
- SLC12A1
Mechanisms of action (all sources)
- Sodium channel blocker
- SCNN1A BLOCKER
- Amiloride-sensitive sodium channel, ENaC blocker
- SCNN1B BLOCKER
- SCNN1G BLOCKER
- SCNN1A MODULATOR
- SCNN1B MODULATOR
- SCNN1G MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- NR1I2
- ABCB1
- NFE2L2
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- MTOR
- NFKB1
- MAPK3
- NPY1R
- NPY2R
- NR1H4
- NR3C1
- NTSR1
- OPRD1
- OPRK1
- MBNL1
- MAPK14
- HRH3
- MAPK1
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR5A
- HTR6
- HTR7
- IDH1
- JAK2
- KAT2A
- KCNH2
- KDM4E
- KDR
- LCK
- LMNA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- ANDR
- THB
- SMAD2
- RUNX1
- RARA
- PEBB
- PAH
- NSD2
- NF2L2
- LYAG
- KLK7
- IDHC
- HXA9
- HSPB1
- HDAC9
- GPX1
- GLI3
- ESRRA
- CP2D6
- CP1A2
- CASP3
- ATF6
- TR10B
Drug classes
- Potassium-sparing Diuretic
- Diuretics
- Epithelial Sodium Channel Blockers
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Channel Blockers
ATC classes
- C03D · ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM-SPARING AGENTS
Cross-references
Synonyms
- DYAZIDE
- DYRENIUM
- Dyrenium
- MAXZIDE
- MAXZIDE-25
- TRIAMTERENE AND HYDROCHLOROTHIAZIDE
- diurene
- pterofen
- pterophene
- triamteren
- triamteril
- triteren
- Triamtereno
- NSC-639359
- NSC-77625
- SK&F-8542
- SK-8542
- Dytac
- Triamterene component of dyazide
- Triamterene component of maxzide
- Ademin
- Ademine
- Amteren
- Anjal
- Dazid
- Diarol
- Dinazide
- Diren
- Ditak
- Diucelpin
- Diurene
- Diutensat
- Diuteren
- Dyberzide
- Dyren
- Dytenzide
- Esiteren
Reported adverse events
- Hyperkalemia
- Hypersensitivity
- Leukopenia
- Thrombocytopenia
- Stevens-Johnson syndrome
- Erythema multiforme
- Arrhythmia
- Diabetes mellitus
- Jaundice
- Xanthopsia
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