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SAQUINAVIR
SynDRA canonical compound SYN0000956 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | CYP3A4 | CYP3A5 |
|---|
| Mechanism of action | HIV protease inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP3A4
- ABCB1
- Htr1a
- pol
- gag-pol
- TBXAS1
- TACR2
- SLC6A3
- OPRM1
- OPRK1
- OPRD1
- HTR1A
Mechanisms of action (all sources)
- protease inhibitor
- HIV PR INHIBITOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- ESR2
- DRD2
- KCNH2
- CACNA1C
- ESR1
- NFE2L2
- MMP9
- MMP1
- NFKB1
- MAPK1
- MLNR
- NPY1R
- MC5R
- NPY2R
- MC4R
- MC3R
- NR1H4
- MAPK3
- MAPK14
- LMNA
- MAOA
- NTSR1
- LCK
- KDM4A
- IDH1
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HRH3
- HRH2
- HRH1
- HMGCR
- NR3C1
- PDE3A
- HDAC6
- SLCO2B1
- SLC29A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADA10
- ANDR
- RARA
- PRGR
- PLCG1
- NR1I2
- NF2L2
- MRGPRX1
- KCMB2
- KCMB1
- KCMA1
- IL1B
- IDHC
- GLI3
- ESRRA
- CP3A4
- CP2D6
- CP2C9
- CP19A
- CASP7
- CASP3
- CACNA1S
- CACNA1F
- CACNA1D
- CAC1H
- TSHR
Drug classes
- HIV Protease Inhibitors
- Protease Inhibitor
- Cytochrome P450 3A Inhibitors
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Protease Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- FORTOVASE
- INVIRASE
- invirase
- saquinavir methanesulfonate
- sequinavir
- fortovase
- saquinavir mesylate
- saquinavir mesilate
- Saquinavirum
- RO-31-8959/000
- SCH-52852
- Fortovase
- Invirase
- ROC
- SQV
- Saguinavir
- Ro 318959
- Fortovase (TN)
- Fortovase(TM)
- Invirase (TN)
- Ro-31-8959
- Invirase(TM)(monomesylate)
- Saquinavir (JAN/USP/INN)
- QNC-ASN-HPH-DIQ-NTB
- Sch 52852
- Ro-31-8959/000
- L3JE09KZ2F
- saquinavir (usp impurity)
- CHEBI:63621
- NSC722663
- Saquinivir
- saquinaviri mesilas
- RefChem:57420
- Monomethanesulfonate, Saquinavir
- DTXCID4024012
- J05AE01
- Ro 31 8959
- MFCD00866925
Reported adverse events
- Diabetes mellitus
- Vomiting
- Bronchitis
- Constipation
- Eczema
- Fatigue
- Infection
- Influenza
- Nausea
- Pneumonia
- Pruritus
- Rash
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