← SynDRA
LORAZEPAM
SynDRA canonical compound SYN0000940 — structure-anchored drug synonym record
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRQ |
|---|
| Mechanism of action | Benzodiazepine receptor agonist |
|---|
All known targets
- GABRB3
- GABRA1
- GABRG2
- GABRP
- GABRG3
- GABRG1
- GABRE
- GABRD
- GABRB2
- GABRB1
- GABRA6
- GABRA5
Mechanisms of action (all sources)
- Benzodiazepine receptor agonist
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA4 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 POSITIVE ALLOSTERIC MODULATOR
- GABRQ POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRP POSITIVE ALLOSTERIC MODULATOR
- GABRD POSITIVE ALLOSTERIC MODULATOR
- GABRG1 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- NR3C1
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HCAR2
- GPR65
- GPR4
- NPY2R
- NTSR1
- ADORA1
- OPRD1
- UGT2B4
- UGT2B10
- UGT1A9
- UGT1A6
- UGT1A1
- TDP1
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anti-Anxiety Agents
- Anticonvulsants
- Antiemetics
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Gastrointestinal Agents
- Hypnotics and Sedatives
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
ATC classes
Cross-references
Synonyms
- ATIVAN
- Ativan
- LORAZ
- LORAZEPAM INTENSOL
- LORAZEPAM PRESERVATIVE FREE
- LOREEV XR
- ativan
- Wy-4036
- NSC-289758
- WY-4036
- Abbloraz
- Loraz
- Lorazepam intensol
- Lorazepam preservative free
- Loreev xr
- Temesta
- Lorazepam civ
- Almazine
- Alzapam
- Anxiedin
- Anxira
- Anzepam
- Aplacasse
- Aplacassee
- ApoLorazepam
- Aripax
- Azurogen
- Bonatranquan
- Bonton
- Delormetazepam
- Demethyllormetazepam
- Donix
- Duralozam
- Durazolam
- Efasedan
- Emotion
- Emotival
Reported adverse events
- Nausea
- Hypotension
- Coma
- Hallucination
- Headache
- Vomiting
- Somnolence
- Injection site reaction
- Acidosis
- Cystitis
- Hyperventilation
- Hypoventilation
Look up LORAZEPAM in the interactive SynDRA portal →