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NIACIN
SynDRA canonical compound SYN0000896 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HCAR3 |
|---|
| Mechanism of action | NAD precursor with lipid lowering effects |
|---|
| Indication | hypertriglyceridemia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- HCAR2
- HCAR3
- DGAT2
- HCAR1
- NNMT
- QPRT
- APP
- Hcar2
- NAMPT
Mechanisms of action (all sources)
- NAD precursor with lipid lowering effects
- HCAR1 AGONIST
- HCAR2 FULL AGONIST
- HCAR3 FULL AGONIST
- NAD precursor
- DGAT2 INHIBITOR
- HCAR2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- KDM4A
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- NTSR1
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GLP1R
- GIPR
- NR3C1
- OPRD1
- GCGR
- SLC29A1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SREBF2
- SLCO2B1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CP2D6
- NF2L2
- SNCA
- SYUA
- TRHR
Drug classes
- Nicotinic Acid
- Antimetabolites
- Cardiovascular Agents
- Hypolipidemic Agents
- Lipid Regulating Agents
- Micronutrients
- Vasodilator Agents
- Vitamin B Complex
- Vitamins
- Vitamin B
ATC classes
- C10A · LIPID MODIFYING AGENTS, PLAIN
- C04A · PERIPHERAL VASODILATORS
- LIPID MODIFYING AGENTS, COMBINATIONS
Cross-references
Synonyms
- NIACOR
- NIASPAN
- NIASPAN TITRATION STARTER PACK
- NICOLAR
- Niacor
- Niaspan
- Slo-Niacin
- WAMPOCAP
- nicotinic acid
- niacin potassium
- niacin magnesium
- vitamin b3 (niacin)
- 3-pyridinecarboxylic acid
- niaspan
- niacor
- Vitamin B3
- aluminium nicotinate
- alcotine
- aluminate nicotinate
- alunitine nicolex
- nicalex
- Nicotinic acid
- Acide nicotinique
- Acido nicotinico
- Acidum nicotinicum
- Niacin extended release
- Nicotinate
- Vitamin b3
- NSC-169454
- Niacin component of advicor
- Niacin component of simcor
- Niacin td
- Niaspan er
- Niaspan titration starter pack
- Nicangin
- Nicolar
- Wampocap
Reported adverse events
- Atrial fibrillation
- Dyspepsia
- Headache
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