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KETOPROFEN
SynDRA canonical compound SYN0000885 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- SLC5A8 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SLC22A6
- NR1I2
- ABCC2
- MMP9
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- NPY1R
- MAPK3
- NPY2R
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- MAPT
- MAPK14
- PDE4D
- HTR2C
- HRH1
- HRH2
- HSD17B10
- HTR1A
- HTR2A
- HTR2B
- HTR3A
- MAPK1
- HTR6
- KCNH2
- KDM4E
- LCK
- LMNA
- MAOA
- PDE3A
- PDE5A
- HMGCR
- UGT1A1
- SMN1
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CFTR
- CP1A2
- CP2C9
- CP2CJ
- CP3A7
- GOPC
- MDR1
- SC5A8
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Cross-references
Synonyms
- ACTRON
- Ketofen
- Ketomed
- Kiprofen
- NEXCEDE
- ORUDIS
- ORUDIS KT
- ORUVAIL
- Orudis
- RP-19583
- ketoprofene
- ketoprophen
- Ketoprofene
- Ketoprofeno
- (rs)-ketoprofen
- Actron ketoprofen
- Aneol
- Capisten
- Hydratropic acid, m-benzoyl-
- Iso-k
- Ketorin
- Sector
- 19583RP
- IDEA-033
- NSC-758144
- R.P. 19,583
- R.P. 19583
- RU-4733
- Actron
- Alrheumat
- Axorid
- Fenoket 200
- Jomethid xl
- Ketocid 200
- Ketonal
- Ketotard 200 xl
- Ketovail
Reported adverse events
- Rash
- Peptic ulcer
- Dyspepsia
- Headache
- Thirst
- Alopecia
- Amnesia
- Arrhythmia
- Chills
- Conjunctivitis
- Diabetes mellitus
- Dysphoria
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