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SULINDAC
SynDRA canonical compound SYN0000867 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | AKR1B1 | PTGS1 | PTGS2 |
|---|
| Mechanism of action | cyclooxygenase inhibitor |
|---|
| Indication | ankylosing spondylitis | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS1
- PTGS2
- AKR1B1
- Abcb11
- Akr1b1
- C5
- GLO1
- GLRA1
- MMP2
- PPARG
- PTGES
- RXRA
Mechanisms of action (all sources)
- PTGS2 INHIBITOR
- Cyclooxygenase inhibitor
- PTGS1 INHIBITOR
- AKR1B1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AKR1B10
- ABCC2
- MAPT
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MBNL1
- KDM4E
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- LCK
- KCNH2
- NPY1R
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- GIPR
- NPSR1
- NPY2R
- GCGR
- SAMHD1
- VDR
- USP1
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- ESRRA
- NF2L2
- NR1I2
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antineoplastic Agents
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
- Tocolytic Agents
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Cross-references
Synonyms
- CLINORIL
- MK231
- MK 231
- clinoril
- Sulindaco
- Arthrocine
- Artribid
- MK-231
- NSC-757344
- Clinoril
- Aclin
- Aflodac
- Arthrobid
- Chibret
- Copal
- Copals
- Kenalin
- Klinoril
- Mobilin
- Sulindacum
- Sulindal
- Alphapharm Brand of Sulindac
- Apo-Sulin
- Apotex Brand of Sulindac
- Cahill May Roberts Brand of Sulindac
- Chemia Brand of Sulindac
- Copal resin
- Copal rosin varnish
- Gum copal
- KendrickBrand of Sulindac
- Merck Brand of Sulindac
- Novo-Sundac
- Novopharm Brand of Sulindac
- Nu-Pharm Brand of Sulindac
- Nu-Sulindac
- Resin copal
- Sulindac sulfoxide
Reported adverse events
- Depression
- Erythema multiforme
- Hypersensitivity
- Hypersensitivity vasculitis
- Pancreatitis
- Peptic ulcer
- Rash
- Stevens-Johnson syndrome
- Thrombocytopenia
- Vertigo
- Ageusia
- Stomatitis
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