← SynDRA

PERPHENAZINE

SynDRA canonical compound SYN0000864 — structure-anchored drug synonym record

All known targets

• DRD2
• HRH1
• HTR7
• HTR6
• HTR2C
• HTR2A
• ADRA1A
• KCNH2
• Htr7
• Htr6
• HTR1A
• DRD4

Mechanisms of action (all sources)

• Dopamine receptor antagonist
• DRD2 ANTAGONIST
• Dopamine D2 receptor antagonist
• HTR2A ANTAGONIST
• HTR2C ANTAGONIST
• HTR6 INVERSE AGONIST
• HTR7 INVERSE AGONIST
• HRH1 ANTAGONIST

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• HTR2B
• GPR65
• FPR3
• SLC6A3
• SLC6A4
• CYP2D6
• NR1I2
• GLP1R
• GPR119
• GPR183
• APLNR
• GPR35
• OPRK1
• ADRB2
• CX3CR1
• CYP1A2
• FPR1
• NTHL1
• OGG1
• NPSR1
• OPRD1
• NR3C1
• OPRM1
• NPY2R
• PDE3A
• PDE4D
• PDE5A
• NPY1R
• NOX1
• NPC1
• NFKB1
• NEIL2
• NEIL1
• MTOR
• MPHOSPH8
• MMP9
• MMP1
• MLNR
• MC5R
• MC4R

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• 5HT2A
• NPR2
• KCMB1
• KCMB2
• KCMB4
• KSYK
• M4K2
• MDR1
• MLLT3
• NSD2
• 5HT2C
• PAFA
• PPCEL
• RARA
• RPGF4
• SMAD2
• SYK
• TOR1A
• KCMA1
• IFNG
• GLI3
• GEMI
• 5HT6R
• 5HT7R
• ACM1
• ACM4
• ACM5
• ALR
• ANDR
• APAF
• CASP3
• CASP7
• CP1A2
• CP2CJ
• CP2D6
• CP3A7
• ESRRA
• TPO

Drug classes

• Antipsychotic Agents
• Central Nervous System Agents
• Central Nervous System Depressants
• Dopamine Agents
• Dopamine Antagonists
• Neurotransmitter Agents
• Psychotropic Drugs
• Tranquilizing Agents
• Phenothiazine

ATC classes

• N05A · ANTIPSYCHOTICS

Cross-references

• PubChem CID: 4748
• ChEMBL: CHEMBL567
• DrugBank: DB00850
• ChEBI: CHEBI:8028
• KEGG: D00503
• RxNorm: 8076
• Wikipedia: Perphenazine
• TTD: D02HED
• LINCS BRD: BRD-K10995081

Synonyms

• ETRAFON 2-10
• ETRAFON 2-25
• ETRAFON-A
• ETRAFON-FORTE
• PERPHENAZINE AND AMITRIPTYLINE HYDROCHLORIDE
• TRIAVIL 2-10
• TRIAVIL 2-25
• TRIAVIL 4-10
• TRIAVIL 4-25
• TRIAVIL 4-50
• TRILAFON
• perfenazine
• perfenil
• perphenan
• perphenazin
• thilatazin
• tranquisan
• perphanzine
• Perfenazina
• Perphenazine maleate
• NSC-150866
• Chlorpiprazine
• Decentan
• Fentazin
• Perphenazine component of etrafon-a
• Trilafon
• Trilafon-la
• Chlorperphenazine
• Emesinal
• Etaperazin
• Etaperazine
• Ethaperazine
• Fentazin;PZC
• Perfenazine
• Perphenan
• Perphenazin
• Perphenazinum

Reported adverse events

• Dyskinesia
• Neuroleptic malignant syndrome
• Sudden death
• Hyperreflexia
• Jaundice
• Dystonia
• Agranulocytosis
• Dry mouth
• Urticaria
• Akathisia
• Alopecia
• Anaphylactoid reaction