← SynDRA
ACETAMINOPHEN
SynDRA canonical compound SYN0000856 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | fever | pain relief |
|---|
| Disease area | endocrinology | neurology/psychiatry |
|---|
All known targets
- PTGS2
- PTGS1
- TRPV1
- FAAH
- TRPV4
- Ca13
- SLC6A4
- SLC6A2
- NR1I3
- MB
- Ca15
- ALOX15
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- FAAH INHIBITOR
- Anandamide amidohydrolase inhibitor
- TRPV1 OPENER
- Vanilloid receptor opener
- TRPV4 INHIBITOR
- SLC6A2 INHIBITOR
- SLC6A4 INHIBITOR
- CNR1 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- RARA
- ABCB1
- NR1I2
- MMP9
- NPY1R
- NPY2R
- NR1H2
- NR1H3
- NR1H4
- NR3C1
- MLNR
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4A
- PDE4D
- MMP1
- MGLL
- PGR
- MC5R
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR6
- KCNH2
- KDR
- LCK
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MAPT
- MC3R
- MC4R
- PDE5A
- PPARA
- ACHE
- UGT1A6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Antipyretics
- Central Nervous System Agents
- Peripheral Nervous System Agents
- Sensory System Agents
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
ATC classes
- N02B · OTHER ANALGESICS AND ANTIPYRETICS
- OPIOIDS
Cross-references
Synonyms
- ACEPHEN
- ACETAMINOPHEN AND CODEINE PHOSPHATE
- ACETAMINOPHEN AND HYDROCODONE BITARTRATE
- ACETAMINOPHEN AND IBUPROFEN
- ACETAMINOPHEN AND PENTAZOCINE HYDROCHLORIDE
- ACETAMINOPHEN, ASPIRIN AND CAFFEINE
- ACETAMINOPHEN, ASPIRIN, AND CODEINE PHOSPHATE
- ACETAMINOPHEN, CAFFEINE AND DIHYDROCODEINE BITARTRATE
- ACETAMINOPHEN, CAFFEINE, AND DIHYDROCODEINE BITARTRATE
- ADVIL DUAL ACTION WITH ACETAMINOPHEN
- ALLAY
- paracetamol
- acetaminofen
- aminofen
- panadol
- neopap
- Paracetamol
- Biocetamol
- Doliprane
- Efferalgan
- N-acetyl-p-aminophenol
- P-hydroxy-acetanilid
- Paracetamolum
- Vermidon
- NSC-109028
- NSC-3991
- Abdine
- Acetaminophen component of allay
- Acetaminophen component of anexsia
- Acetaminophen component of anoquan
- Acetaminophen component of apadaz
- Acetaminophen component of bancap
- Acetaminophen component of bancap hc
- Acetaminophen component of bucet
- Acetaminophen component of butapap
- Acetaminophen component of co-gesic
- Acetaminophen component of codrix
Reported adverse events
- Hepatotoxicity
- Acetaminophen
- NGS
- Death
- Addiction
- TEN
- Respiratory depression
- Depression
- Accident
- Caffeine
- Phosphate
- ECT
Look up ACETAMINOPHEN in the interactive SynDRA portal →