← SynDRA
PROMAZINE
SynDRA canonical compound SYN0000848 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | DRD2 |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- HTR2A
- CHRM5
- DRD4
- CHRM2
- DRD1
- CHRM4
- CHRM3
- ADRA1A
- HRH1
- HTR2C
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- DRD2 ANTAGONIST
- D2-like dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
- CHRM5 BINDER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR7
- KDM1A
- OPRK1
- OPRM1
- MALT1
- HTR5A
- ADRB2
- KCNH2
- MMP1
- IDH1
- OPRD1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- NOX1
- MTOR
- MPHOSPH8
- MMP9
- MLNR
- KDM4E
- MC5R
- MC4R
- KAT2A
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- MC3R
- ACHE
- PDE3A
- SLCO1B1
- USP1
- TSHR
- TP53
- THPO
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ACM4
- ACM5
- ALR
- ANDR
- CFTR
- CP1A2
- CP2CJ
- CP2D6
- CP3A7
- GCR
- GLI3
- GSTP1
- JUN
- NTM1A
- RARA
Drug classes
- Antiemetics
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Gastrointestinal Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- PROMAZINE HYDROCHLORIDE
- SPARINE
- prazin
- prazine
- romtiazin
- promazine hydrochloride
- promazine HCl
- Promazina
- Combelen
- NSC-31447
- Ampazine
- Berophen
- Esparin
- Liranol
- Prazin
- Prazine
- Promazin
- Promazinum
- Promwill
- Propazinum
- Protactyl
- Romtiazin
- Sinophenin
- Tomil
- Verophen
- Combelen [veterinary]
- Promazina [Italian]
- A 145
- RP 3276
- Wy-1094
- Combelen [veterinary] (TN)
- Neo-Hibernex
- Promazina [INN-Spanish]
- Promazine (INN)
- Promazine [INN:BAN]
- Promazinum [INN-Latin]
- Sparine (TN)
- N-(3-Dimethylaminopropyl)phenothiazine
Look up PROMAZINE in the interactive SynDRA portal →