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FLURBIPROFEN
SynDRA canonical compound SYN0000844 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS1 | PTGS2 |
|---|
| Mechanism of action | cyclooxygenase inhibitor |
|---|
| Indication | osteoarthritis | rheumatoid arthritis |
|---|
| Disease area | rheumatology |
|---|
All known targets
- PTGS2
- PTGS1
- AKR1C2
- AKR1C3
- FABP2
- Fabp1
- Ptgs1
- Ptgs2
- SLC36A1
Mechanisms of action (all sources)
- PTGS2 INHIBITOR
- Cyclooxygenase inhibitor
- PTGS1 INHIBITOR
- SLC36A1 INHIBITOR
- PTGS2 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CHRM3
- ADRA2B
- AKR1C4
- AKR1C1
- DRD3
- HTR2C
- SLC22A6
- ESR1
- MMP1
- MLNR
- MAOB
- MMP9
- MC4R
- NPY1R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- NPY2R
- NR1I2
- MC5R
- ABCC2
- NR3C1
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- MAOA
- OPRK1
- OPRD1
- GLP1R
- UGT2B7
- UGT1A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- HDAC9
- KAPCB
- KIFAP3
- PPARG
Drug classes
- Cyclooxygenase Inhibitors
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Central Nervous System Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- Nonsteroidal Anti-inflammatory Drug
- analgesic agent
ATC classes
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- S01B · ANTIINFLAMMATORY AGENTS
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- R02A · THROAT PREPARATIONS
Cross-references
Synonyms
- ANSAID
- Ansaid
- FLURBIPROFEN SODIUM
- OCUFEN
- Ocufen
- (+/-)-Flurbiprofen
- fluribiprofen
- fluroben
- flurofen
- dl-Flurbiprofen
- flurbiprofen sodium
- Flubiprofen
- Flurbiprofene
- Flurbiprofeno
- BTS 18,322
- BTS-18322
- NSC-757037
- U-27,182
- U-27182
- Cebutid
- Froben
- Froben sr
- Strefen
- Transact
- Adfeed
- Adofeed
- Anmetarin
- Anside
- Antadys
- FLP
- Flugalin
- Flurbiprofenum
- Fluriproben
- Flurofen
- Ocuflur
- Stayban
- Yakuban
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Elderly
- Rash
- Hypertension
- Perforation
- Hepatotoxicity
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