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NOMIFENSINE
SynDRA canonical compound SYN0000836 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | SLC6A3 |
|---|
| Mechanism of action | Noradrenaline uptake inhibitor |
|---|
| Indication | depression |
|---|
| Disease area | Antidepressant |
|---|
All known targets
- SLC6A2
- SLC6A3
- SLC6A4
- DRD2
- HBA1
- HBB
- HRH1
- HTR1A
- MAOA
- MPO
- NET
- Slc6a2
Mechanisms of action (all sources)
- Dopamine uptake inhibitor
- Noradrenaline uptake inhibitor
- SLC6A4 INHIBITOR
- Monoamine transporter inhibitor
- SLC6A3 INHIBITOR
- SLC6A2 INHIBITOR
- dopamine reuptake inhibitor
- DRD2 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PTGS2
- KCNH2
- DRD3
- OPRM1
- ADORA1
- OPRD1
- NR3C1
- NR1I2
- NPY1R
- NFKB1
- MLNR
- MAPK1
- MC3R
- LMNA
- KMT2A
- HTR3A
- HTR2C
- HTR2B
- OPRK1
- PABPC1
- HRH3
- SENP1
- TBXA2R
- TARDBP
- SMN1
- SLCO1B3
- SLCO1B1
- SLC29A1
- SAMHD1
- PDE3A
- RGS4
- POLB
- PMP22
- PIN1
- PGR
- PDE4D
- HTR2A
- HRH2
- ADORA2A
- AGTR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- B2CL1
- CP2D6
- CP3A4
- CP3A7
- GLI3
- GLSK
- MCL1
- MDR1
- NTM1A
- TNNC1
- TNNI3
- TNNT2
Drug classes
- Dopamine Agents
- Dopamine Uptake Inhibitors
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
ATC classes
Cross-references
Synonyms
- merital
- nomifensine maleate
- (+/-)-Nomifensin
- (+/-)-Nomifensine
- linamiphen
- nomifensin
- Nomifensina
- Linamiphen
- Nomifensin
- Nomifenison
- Nomifensinum
- Nomiphensine
- Nomifensina [INN-Spanish]
- Nomifensine [INN:BAN]
- Nomifensine maleate(USAN)
- Nomifensinum [INN-Latin]
- D,L-nomifensine
- Nomifensine Maleate (1:1)
- R/S-nomifensine
- (+)-Nomifensine
- (+)-Nomiphensine
- (+-)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
- (+-)-Nomifensin
- (+-)-Nomifensine
- (R)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine
- 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine
- 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-8-isoquinolinamine 2-butenedioate
- 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine
- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine
- 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine
- 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisochinolin
- 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline
- 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline maleate (1:1)
- 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline
- 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl
- 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-(9CI)
- 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
- 1LGS5JRP31
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