← SynDRA
MEXILETINE
SynDRA canonical compound SYN0000824 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN5A |
|---|
| Mechanism of action | Sodium channel blocker |
|---|
| Indication | ventricular arrhythmias | ventricular tachycardia (VT) |
|---|
| Disease area | cardiology |
|---|
All known targets
- SCN5A
- SCN4A
- SCN9A
- SCN10A
- SCN1A
- SCN2A
- KCNK3
- SCN8A
- SCN11A
- SCN7A
- SCN3A
- CYP2B6
Mechanisms of action (all sources)
- Sodium channel blocker
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
- SCN10A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- MAOA
- NPY2R
- NPY1R
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- LMNA
- NR3C1
- LCK
- KAT2A
- HTR6
- HTR2C
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GHSR
- NR1I2
- OPRD1
- ADORA1
- SAMHD1
- UGT2B4
- UGT2B10
- TBXAS1
- TACR2
- TACR1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2D6
- IF4G1
- TNNC1
- TNNI3
- TNNT2
Drug classes
- Antiarrhythmic
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Sodium Channel Blockers
- Voltage-Gated Sodium Channel Blockers
ATC classes
- C01B · ANTIARRHYTHMICS, CLASS I AND III
Cross-references
Synonyms
- MEXILETINE HYDROCHLORIDE
- MEXITIL
- dl-mexiletine
- (+/-)-Mexiletine
- (RS)-Mexiletine
- mexiletine hydrochloride
- mexiletin hydrochloride
- mexiletine HCl
- mexiletin HCl
- Mexiletina
- (rs)-mexiletine
- Dl-mexiletine
- Mexiletene
- Mexiletinum
- Mexilitine
- Mexityl
- Mexiletine HCL
- KO1173
- KO-1173
- KOE-1173
- Mexiletina [INN-Spanish]
- Mexiletine (INN)
- Mexiletine [INN:BAN]
- Mexiletinum [INN-Latin]
- Mexitil (TN)
- 2-(2-Aminopropoxy)-1,3-DiMethyl-Benzene Hydrochloride
- 2-(2-aminopropoxy)-1,3-dimethylbenzene
- Mexitil
- CHEMBL558
- 1U511HHV4Z
- CHEBI:6916
- MEXILETINE [INN]
- NCGC00015659-06
- EINECS 250-825-7
- BRN 2092205
- UNII-1U511HHV4Z
- Mexitil (Salt/Mix)
- Mexiletinehydrochloride
Reported adverse events
- Eosinophilia
- Headache
- Nausea
- Vomiting
- Palpitations
- Tinnitus
- Constipation
- Rash
- Syncope
- Tremor
- Fatigue
- Arthralgia
Look up MEXILETINE in the interactive SynDRA portal →