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VALPROIC ACID
SynDRA canonical compound SYN0000804 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ALDH5A1 |
|---|
| Mechanism of action | Voltage-gated sodium channel blocker |
|---|
| Indication | epilepsy | seizures |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ALDH5A1
- HDAC1
- ABAT
- HDAC2
- SCN3A
- SCN1A
- SCN1B
- SCN9A
- SCN8A
- SCN7A
- SCN5A
- SCN4B
Mechanisms of action (all sources)
- histone deacetylase inhibitor
- GABA receptor agonist
- GABAergic transmission enhancer
- Voltage-gated sodium channel blocker
- ALDH5A1 INHIBITOR
- Succinate semialdehyde dehydrogenase inhibitor
- HDAC1 INHIBITOR
- benzodiazepine receptor agonist
- ABAT INHIBITOR
- GSK3A INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH1
- ADRA1A
- DRD3
- CHRM1
- CHRM3
- SLC6A3
- HTR2A
- PDE4A
- NPY2R
- MMP9
- NFE2L2
- NFKB1
- NPSR1
- NPY1R
- PDE5A
- PDE4D
- PDE3A
- NR3C1
- MMP1
- OPRD1
- OPRK1
- OPRM1
- NTSR1
- MLNR
- POLK
- MC5R
- HRH3
- HTR1A
- HTR2B
- HTR2C
- HTR3A
- HTR6
- HTR7
- KAT2A
- KCNH2
- LCK
- LTA4H
- MAOA
- MAPK1
- MAPK14
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anticonvulsants
- Antimanic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Enzyme Inhibitors
- GABA Agents
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Mood Stabilizer
- Anti-epileptic Agent
ATC classes
Cross-references
Synonyms
- DEPACON
- DEPAKENE
- DEPAKOTE
- DEPAKOTE CP
- DEPAKOTE ER
- DIVALPROEX SODIUM
- Depakote
- STAVZOR
- VALPROATE SODIUM
- divalproex disodium
- 2-Propylpentanoic acid
- dipropylacetic acid
- epival
- divalproex sodium
- depakote
- valdisoval
- valproate semisodium
- valproate sodium
- sodium valproate
- divalproex
- propylisopropylacetic acid
- magnesium valproate
- valproate calcium
- Acide valproique
- Acido valproico
- Pentanoic acid, 2-propyl
- Valproate
- Valproic acid extended release
- 44089
- NSC-93819
- Convulex
- Depakene
- Stavzor
- Divalproex sodium
- Delepsine
- Divalproate
- Divalproex
Reported adverse events
- Hepatotoxicity
- Pancreatitis
- Hepatic failure
- TEN
- LP
- CAT
- DIC
- OC
- P
- Stevens-Johnson syndrome
- Weight
- Somnolence
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