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CARBAMAZEPINE
SynDRA canonical compound SYN0000800 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN5A |
|---|
| Mechanism of action | Carboxamide antiepileptic |
|---|
| Indication | seizures |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SCN5A
- SCN9A
- SCN4A
- SCN3A
- SCN1A
- SCN10A
- SCN8A
- SCN7A
- SCN2A
- SCN11A
- FZD8
- ABCB1
Mechanisms of action (all sources)
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
- SCN10A BLOCKER
- FZD8 NEGATIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- ACHE
- P2RX4
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MDH1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- IDH1
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- PDE5A
- PPP3CA
- PRKCA
- TACR2
- USP1
- UGT2B7
- UGT1A9
- UGT1A6
- UGT1A4
- UGT1A3
- UGT1A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ANDR
- CP2CJ
- CP2D6
- GCR
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anticonvulsants
- Antimanic Agents
- Cardiovascular Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Cytochrome P-450 CYP3A Inducers
- Membrane Transport Modulators
- Metabolic Side Effects of Drugs and Substances
- Peripheral Nervous System Agents
- Psychotropic Drugs
ATC classes
Cross-references
Synonyms
- CARBATROL
- CARNEXIV
- Carbatrol
- EPITOL
- EQUETRO
- Epitol
- Equetro
- TEGRETOL
- TEGRETOL-XR
- TERIL
- Tegretol
- carbamazepen
- carbamazepin
- carbazepine
- carbamazepine dihydrate
- carbamazepine hydrate
- carbamazepine hydrochloride
- carbamazepine sulfate
- carbamazepine anhydrous
- carbamazepine phosphate
- carbamazepine tartrate
- Carbamazepina
- Biston
- Carbamazepine anhydrous
- Carbamazepine extended release
- Carbamazepinum
- Finlepsin
- Karbamazepin
- Karbelex
- Neurotol
- Neurotop
- Sirtal
- Stazepine
- Tegretal
- Telesmin
- Timonil
- G-32883
Reported adverse events
- OC
- P
- TEN
- Dizziness
- Nausea
- Pancreatitis
- Albuminuria
- Myocardial infarction
- Testicular atrophy
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Osteoporosis
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