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BICUCULLINE
SynDRA canonical compound SYN0000790 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | GABRA1 | GABRA2 | GABRA3 | GABRA4 | GABRA5 | GABRA6 | KCNN1 |
|---|
| Mechanism of action | GABA receptor antagonist |
|---|
All known targets
- GABRA1
- GABRA2
- GABRA3
- GABRA4
- GABRA5
- GABRA6
- KCNN1
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CBX1
- EHMT2
- GMNN
- HDAC6
- SAMHD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- GABRB1
- GABRQ
- KSYK
- GBRA6
- GBRA5
- GBRA4
- GBRA3
- GBRA2
- GABRP
- GABRB2
- GABRG3
- GABRG2
- GABRG1
- GABRE
- GABRD
- GABRB3
- SYK
Drug classes
- Convulsants
- GABA-A Receptor Antagonists
Cross-references
Synonyms
- (+)-Bicuculline
- d-Bicuculline
- Bicculine
- Bicucullin
- Bicuculline (+)
- UNII-Y37615DVKC
- NSC 32192
- C20H17NO6
- EINECS 207-619-7
- BRN 0098786
- CHEMBL417990
- CHEBI:3092
- Y37615DVKC
- (6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
- NSC32192
- Furo(3,4-e)-1,3-benzodioxol-8(6H)-one, 6-(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)-, (R-(R*,S*))-
- RefChem:119660
- DTXCID1022687
- bicuculline-(+)
- MFCD00005006
- SR-01000075252
- D-Bic uculline
- IYGYMKDQCDOMRE-ZWKOTPCHSA-N
- Bicuculline,(+)
- Prestwick_96
- (+)-Bicuculline?
- Bicuculline (Standard)
- BICUCULLINE [MI]
- Prestwick0_000589
- Prestwick1_000589
- Prestwick2_000589
- Prestwick3_000589
- Biomol-NT_000252
- (+)-Bicuculline, 98%
- SCHEMBL8222
- Lopac0_000234
- BSPBio_000438
- 4-27-00-06900 (Beilstein Handbook Reference)
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