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COLCHICINE
SynDRA canonical compound SYN0000772 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TUBB1 |
|---|
| Mechanism of action | Microtubule inhibitor |
|---|
| Indication | fever | gout |
|---|
| Disease area | endocrinology | rheumatology |
|---|
All known targets
- TUBB
- TUBA1A
- TUBB2B
- TUBB1
- TUBB4B
- GLRA1
- GLRA2
- TUBB4A
- TUBB3
- TUBB2A
- TUBA1B
- TUBA1C
Mechanisms of action (all sources)
- microtubule inhibitor
- TUBB4B INHIBITOR
- TUBB1 INHIBITOR
- TUBA3C INHIBITOR
- TUBA4A INHIBITOR
- TUBB3 INHIBITOR
- TUBA1A INHIBITOR
- TUBB4A INHIBITOR
- TUBB8 INHIBITOR
- TUBB INHIBITOR
- TUBA1B INHIBITOR
- TUBA1C INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- SLC22A3
- NR1I2
- HTR2B
- IDH1
- NR1H4
- MMP9
- NFE2L2
- NPSR1
- NPY1R
- NPY2R
- NR0B1
- HTR3A
- MLNR
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PARP1
- PAX8
- MMP1
- HTR6
- JAK2
- MAOA
- KATNA1
- KCNH2
- KDR
- KIF20A
- LCK
- LMNA
- MAPK1
- MC5R
- MAPK14
- MAPK3
- MBNL1
- MC3R
- MC4R
- PDE3A
- ABCC2
- PDE5A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- KSYK
- SYK
- STK33
- SMAD2
- RARA
- NSD2
- NF2L2
- MDR1
- MDM4
- MDM2
- KLF5
- BARD1
- JUN
- IFNG
- GLI3
- GEMI
- ESRRA
- CP2D6
- CP2CJ
- CP2C9
- BRCA1
- YAP1
Drug classes
- P-Glycoprotein Interactions
- Antimitotic Agents
- Antirheumatic Agents
- Gout Suppressants
- Tubulin Modulators
- Cytochrome P450 3A4 Inhibitors
- Alkaloid
ATC classes
- M04A · ANTIGOUT PREPARATIONS
Cross-references
Synonyms
- COL-PROBENECID
- COLBENEMID
- COLCRYS
- Colcrys
- GLOPERBA
- Gloperba
- LODOCO
- Lodoco
- MITIGARE
- Mitigare
- PROBEN-C
- colchisol
- colcin
- (-)-colchicine
- Colchcine
- Colchicinum
- Colchineos
- Colchisol
- NSC-757
- Colchicine component of col-probenecid
- Colchicine component of colbenemid
- Colchicine component of mitigare
- Colchicine component of proben-c
- Colchicin
- Colchicina
- Colchysat
- Colcin
- Colsaloid
- Colstat
- Condylon
- Goutnil
- Kolkicin
- LOC
- Binds to tubulin
- Colchicin [German]
- Colchicina [Italian]
- Colchicine [JAN]
Reported adverse events
- Nausea
- Vomiting
- Fatigue
- Headache
- Prophylaxis
- Hypersensitivity
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