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PILOCARPINE
SynDRA canonical compound SYN0000769 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRM3 |
|---|
| Mechanism of action | Acetylcholine receptor agonist |
|---|
| Indication | glaucoma | hypertension |
|---|
| Disease area | cardiology | ophthalmology |
|---|
All known targets
- CHRM1
- CHRM3
- CHRM2
- CHRM5
- CHRM4
- Chrm1
- Chrm2
- Chrm3
- Chrm4
- Chrm5
- mAChR-A
Mechanisms of action (all sources)
- Acetylcholine receptor agonist
- CHRM3 AGONIST
- Muscarinic acetylcholine receptor M3 agonist
- CHRM1 AGONIST
- Muscarinic acetylcholine receptor M1 agonist
- CHRM5 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2A
- DRD1
- CYP2A6
- CYP2A13
- LMNA
- MAOA
- MAPT
- MBNL1
- MC3R
- OPRD1
- MLNR
- MPHOSPH8
- NPY1R
- NR1I2
- KDM4E
- NR3C1
- KCNH2
- MC4R
- OPRK1
- HTR2C
- OPRM1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC47A2
- SLC47A1
- SLC29A1
- SLC22A1
- SAMHD1
- PTGS2
- PMP22
- PGR
- PDE4D
- PDE3A
- HTR3A
- ADORA1
- HTR2B
- CCKAR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM2
- ACM4
- ACM5
- CP2C9
- CP2CJ
- CP3A4
- GPR151
- M4K2
- MDR1
- PE2R2
- RGS4
Drug classes
- Cholinergic Muscarinic Agonists
- Cholinergic Agonists
- Cholinergic Agents
- Miotics
- Muscarinic Agonists
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Cholinergic Receptor Agonist
ATC classes
- N07A · PARASYMPATHOMIMETICS
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Cross-references
Synonyms
- BETOPTIC PILO
- ISOPTO CARPINE
- Isoptocarpine
- OCUSERT PILO-20
- OCUSERT PILO-40
- PILOCARPINE HYDROCHLORIDE
- PILOPINE HS
- Pilocar
- QLOSI
- Qlosi
- SALAGEN
- Salagen
- salagen
- pilocarpine nitrate
- ocucarpine
- pilocarpol
- pilokarpin
- syncarpine
- (+)-Pilocarpine
- pilocarpine hydrochloride
- pilocarpine HCl
- Ocucarpine
- Pilocarpinum
- Pilocarpol
- Pilokarpin
- Spersacarpine
- Syncarpine
- Ocusert pilo
- Ocusert pilo-20
- Ocusert pilo-40
- Adsorbocarpine
- Almocarpine
- Epicar
- Isopilocarpine
- Miocarpine
- Ocusert
- Pilagan
- Pilocarpin
Reported adverse events
- Headache
- Amblyopia
- Asthenia
- Chills
- Dizziness
- Dyspepsia
- Flushing
- Hypertension
- Infection
- Nausea
- Pain
- Pharyngitis
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