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SELICICLIB
SynDRA canonical compound SYN0000761 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | CDK9 |
|---|
| Mechanism of action | CDK inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- cyclin-dependent kinase inhibitor
- CDK2 INHIBITOR
- Cyclin-dependent kinase 2 inhibitor
- CDK7 INHIBITOR
- Cyclin-dependent kinase 7 inhibitor
- CDK9 INHIBITOR
- Cyclin-dependent kinase 9 inhibitor
- CDK1 INHIBITOR
- Cyclin-dependent kinase 1 inhibitor
- CDK5 INHIBITOR
- Cyclin-dependent kinase 5 inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CSNK1G2
- DYRK1B
- CLK2
- CLK1
- CCAR2
- CCNA2
- ALK
- CCNB1
- CSNK1G1
- RPS6KA2
- TTK
- MAPK1
- DYRK1A
- DYRK2
- CDK12
- ERCC2
- CSNK1G3
- CSNK1E
- CDK16
- CSNK1D
- CDK4
- CLK4
- CSNK1A1
- MAPK15
- PAK4
- PIM1
- PIP4K2C
- PIM3
- PIP4K2B
- PIM2
- PIP4K2A
- AAK1
- PIK3CG
- PIK3CB
- PIK3CA
- PIK3C2G
- PIK3C2B
- PI4KB
- PHKG2
- PHKG1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ATXN2
- CCNA1
- NSD2
- MNAT1
- KC1G3
- KC1E
- KC1D
- IFNB1
- HLAB
- GEM
- DYR1B
- CDK5R1
- CCNT1
- CCNK
- CCNH
- CCNE2
- CCNE1
- CCNB3
- CCNB2
- SMN
Drug classes
- Antineoplastic Agents
- Antiviral Agents
- Protein Kinase Inhibitors
Cross-references
Synonyms
- CYC-202
- R-roscovitine
- Roscovitin
- Roscovitine
- AL-39256
- NSC-701554
- roscovitine
- (R)-roscovitine
- CYC202
- CYC 202
- 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
- UNII-0ES1C2KQ94
- Roscovitine (Seliciclib,CYC202)
- CHEMBL14762
- 0ES1C2KQ94
- CHEBI:45307
- NSC701554
- (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol
- (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
- (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol
- RRC
- Rosco
- M02443
- BMK1-E12
- CYC202, Seliciclib, R-roscovitine, Roscovitine
- (2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol
- 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol
- 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-(R)-1-butanol
- 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
- R roscovitine
- NSC 701554
- seliciclibum
- RefChem:389269
- DTXCID8094419
- Seliciclib [INN]
- Seliciclib (Roscovitine)
- MFCD02266401
- C19H26N6O
- 1unl
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