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ILOPERIDONE
SynDRA canonical compound SYN0000751 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR7 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR2A
- DRD2
- HTR7
- HTR6
- HTR1A
- ADRA1A
- DRD1
- DRD4
- DRD3
- HRH1
- ADRA2C
- CHRM4
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR1A ANTAGONIST
- HTR6 ANTAGONIST
- HTR7 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- SLC6A4
- OPRM1
- CHRNA4
- PDE4A
- MLNR
- NR1I2
- NR3C1
- OPRD1
- OPRK1
- PDE3A
- PDE4D
- MAOA
- PGR
- PPARG
- PTGS1
- PTGS2
- SLC29A1
- TACR1
- TBXA2R
- MC3R
- ABCB11
- ACHE
- HTR3A
- ADORA1
- ADORA2A
- ADORA3
- ADRB1
- ADRB2
- AGTR1
- AR
- AVPR1A
- CCKAR
- CHRM3
- CNR1
- EDNRA
- ESR1
- F2
- GHSR
- HDAC6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT6R
- 5HT7R
- ACES
- ACM1
- CP2D6
- CP3A4
- CP3A7
- GLI3
- GPR32
Drug classes
- Atypical Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- FANAPT
- Fanapt
- HP 873
- zomaril
- fanapt
- Iloperidona
- HP-873
- Fanapta
- Fiapta
- Zomaril
- Fanapt (TN)
- ILO-522
- Iloperidone [USAN:INN]
- Fanapta, Zomaril, Iloperidone
- Iloperidone (USAN/INN)
- VPO7KJ050N
- iloperidone (usp-rs)
- iloperidona
- iloperidonum
- DTXCID7028986
- CHEBI:65173
- RefChem:55393
- N05AX14
- Iloperidone (Fanapt)
- C24H27FN2O4
- Iloperidone-d3
- MFCD00866688
- s1483
- NCGC00188864-01
- SMR002529575
- CAS-133454-47-4
- UNII-VPO7KJ050N
- Iloperidone [USAN:INN:BAN]
- HSDB 8207
- HP873
- PS36 - Iloperidone
- ILOPERIDONE [MI]
Reported adverse events
- Agranulocytosis
- Akathisia
- Arthralgia
- Bradykinesia
- Dizziness
- Dyskinesia
- Dystonia
- Fatigue
- Hypotension
- Lethargy
- Leukopenia
- Nasopharyngitis
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