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CLOTRIMAZOLE
SynDRA canonical compound SYN0000731 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KCNN4 |
|---|
| Mechanism of action | Cytochrome P450 inhibitor |
|---|
| Indication | oropharyngeal candidiasis | vulvovaginal candidiasis |
|---|
| Disease area | infectious disease |
|---|
All known targets
- KCNN4
- NR1I3
- NR1I2
- TRPM2
- CYP3A4
- CYP51A1
- TRPM8
- TRPM4
- ABCB1
- KCNMA1
- NR1H4
- MDH1
Mechanisms of action (all sources)
- Imidazoline ligand
- Cytochrome P450 inhibitor
- NR1I3 ANTAGONIST
- KCNMA1 MODULATOR
- KCNN4 INHIBITOR
- NR1I2 AGONIST
- TRPM2 ANTAGONIST
- TRPM4 ANTAGONIST
- TRPM8 MODULATOR
- imidazoline receptor ligand
- CXCR2 MODULATOR
- ERG11 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- TP53
- CYP1A2
- CYP2C8
- CYP2D6
- CACNA1C
- ESR1
- ESR2
- ADRB2
- KDM4A
- IDH1
- NFKB1
- NFE2L2
- HTR3A
- MPHOSPH8
- HTT
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- KEAP1
- MAPT
- MAPK3
- JUN
- NPY1R
- MAPK14
- MAPK1
- MAOB
- MAOA
- LMNA
- LCK
- L3MBTL1
- NPSR1
- NTSR1
- NPY2R
- HSP90AA1
- VDR
- USP2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- PPARG
- KCNQ1
- KSYK
- MDR1
- MK01
- NF2L2
- NSD2
- PPARD
- PPP1CA
- ACM1
- PRGR
- RARA
- RPGF4
- RXFP1
- S12A5
- SYK
- TPO
- KCNK3
- IFNG
- HSPB1
- HS90A
- AHR
- ANDR
- CP19A
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- GCR
- GEMI
- GLI3
- GPR151
- GPR55
- TRHR
Drug classes
- Azole Antifungal
- 14-alpha Demethylase Inhibitors
- Anti-Infective Agents
- Anti-Infective Agents, Local
- Antifungal Agents
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Hormone Antagonists
- Metabolic Side Effects of Drugs and Substances
- Steroid Synthesis Inhibitors
ATC classes
- A01A · STOMATOLOGICAL PREPARATIONS
- G01A · ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- D01A · ANTIFUNGALS FOR TOPICAL USE
Cross-references
Synonyms
- Aardora Anti-Fungal Maximum Strength
- Alevazol
- CLOTIC
- CLOTRIMAZOLE AND BETAMETHASONE DIPROPIONATE
- Clotic
- Dermatin
- GYNE-LOTRIMIN
- GYNE-LOTRIMIN 3
- GYNE-LOTRIMIN 3 COMBINATION PACK
- GYNE-LOTRIMIN COMBINATION PACK
- GYNIX
- lotrimin
- rimazole
- locasten
- Clotrimazol
- SVT-15652
- Trivagizole
- BAY-5097
- GNF-PF-3499
- NSC-257473
- Abtrim
- Actavall
- Candiden
- Canesten
- Canesten af
- Canesten crm combi
- Canesten internal
- Canesten vc
- Clotrimazole component of lotrisone
- Fungederm
- Gyne-lotrimin
- Gyne-lotrimin 3
- Gyne-lotrimin 3 combination pack
- Gyne-lotrimin combination pack
- Gynix
- Masnoderm
- Mycelex
Reported adverse events
- Cushing's syndrome
- Nausea
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