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KETOTIFEN
SynDRA canonical compound SYN0000673 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | Leukotriene receptor antagonist |
|---|
| Indication | asthma | itching |
|---|
| Disease area | neurology/psychiatry | pulmonary |
|---|
All known targets
- HRH1
- ABCB1
- ADRA1D
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH4
- HRH2
- DRD3
- DRD1
Mechanisms of action (all sources)
- Histamine receptor ligand
- Histamine receptor agonist
- Phosphodiesterase inhibitor
- Leukotriene receptor antagonist
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- histamine receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR7
- DRD5
- KCNH2
- HTR3A
- HTR1D
- HTR1B
- ADRA2C
- TMEM97
- OPRK1
- DRD2
- NPSR1
- NPY1R
- NPY2R
- NR1I2
- NR3C1
- OPRD1
- NTHL1
- OGG1
- NEIL1
- OPRM1
- PDE3A
- NEIL2
- MMP1
- MPG
- MMP9
- PDE5A
- MLNR
- MC5R
- MC4R
- MC3R
- MBD4
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- PDE4D
- ACHE
- IDH1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- ACM4
- ACM5
- ANDR
- CP2CJ
- CP2D6
- CP3A7
- G6PD
- GLI3
- GSR
- KSYK
- PGD
- PLIN5
- SYK
- TLR3
Drug classes
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Inhibitor
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
- S01G · DECONGESTANTS AND ANTIALLERGICS
Cross-references
Synonyms
- ACUVUE THERAVISION WITH KETOTIFEN
- ALAWAY
- Alaway
- CHILDREN'S ALAWAY
- KETOTIFEN FUMARATE
- ZADITOR
- Zaditor
- HC 20-511
- ketotifen fumarate
- Ketotifene
- Ketotifeno
- (r)-ketotifen
- Ketotifenum
- Ketotifin
- Ketotiphen
- Ketotiphene
- Ketotifene fumarate
- Alaway (TN)
- Ketotifen (INN)
- Ketotifen [INN:BAN]
- Ketotifene [INN-French]
- Ketotifeno [INN-Spanish]
- Ketotifenum [INN-Latin]
- Zaditor (TN)
- ketotifen hydrogen fumarate impurity e (ep impurity)
- X49220T18G
- DTXCID203190
- CHEBI:92511
- RefChem:57862
- R06AX17
- S01GX08
- HC-20511 fumarate
- MFCD00599548
- NCGC00015580-08
- KETOTIFEN [INN]
- MLS002222254
- CAS-34580-13-7
- HSDB 7283
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