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PERGOLIDE
SynDRA canonical compound SYN0000653 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | HTR2C |
|---|
| Mechanism of action | Dopamine receptor agonist |
|---|
All known targets
- DRD1
- DRD2
- DRD5
- DRD4
- DRD3
- HTR1D
- HTR1A
- HTR2A
- HTR2B
- HTR2C
- HTR1B
- ADRA2C
Mechanisms of action (all sources)
- Dopamine receptor agonist
- DRD2 AGONIST
- DRD3 AGONIST
- DRD5 AGONIST
- DRD4 AGONIST
- DRD1 AGONIST
- HTR1A PARTIAL AGONIST
- HTR1B FULL AGONIST
- HTR1D PARTIAL AGONIST
- HTR2A FULL AGONIST
- HTR2B FULL AGONIST
- HTR2C PARTIAL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH1
- HRH2
- ABCB11
- MBNL1
- NTSR1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- OPRK1
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- IDH1
- HTR3A
- HRH3
- HMGCR
- HDAC6
- OPRD1
- OPRM1
- ACHE
- PDE3A
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1B
- PABP1
- MDR1
- IF4H
- GPR32
- CP3A7
- CP3A4
- CP2D6
- ADA2C
- ADA2B
- ACES
- 5HT5A
- 5HT2C
- 5HT2B
- 5HT2A
- 5HT1D
- TADA2A
Drug classes
- Dopamine Agonists
- Dopamine Agents
- Neurotransmitter Agents
- Ergot-derived Dopamine Receptor Agonist
ATC classes
- N04B · DOPAMINERGIC AGENTS
Cross-references
Synonyms
- PERGOLIDE MESYLATE
- PERMAX
- Prascend
- LY-127,809
- LY127,809
- permax
- LY 127809
- pergolide mesilate
- pergolide mesylate
- Pergolida
- Pergolidum
- Permax
- Pergolida [INN-Spanish]
- Pergolide (INN)
- Pergolide [INN:BAN]
- Pergolidum [INN-Latin]
- Permax (TN)
- (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
- (8beta)-8-[(methylthio)methyl]-6-propylergoline
- CHEBI:63617
- Parkotil
- Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-
- RefChem:57298
- DTXCID203438
- N04BC02
- 8beta-[(Methylthio)methyl]-6-propylergoline
- PERGOLIDE [INN]
- LY 141B
- NCGC00017366-04
- TNP00315
- UNII-24MJ822NZ9
- SR-01000721840
- Spectrum_001647
- PERGOLIDE [MI]
- Prestwick0_000295
- Prestwick1_000295
- Prestwick2_000295
- Prestwick3_000295
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