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PHENYLBUTAZONE
SynDRA canonical compound SYN0000648 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Prostanoid receptor antagonist |
|---|
All known targets
- PTGS2
- PTGS1
- PTGIS
- CYP2C9
- FPR1
- NAPRT
- Ptgs1
- Ptgs2
- TAS2R2
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- Prostanoid receptor antagonist
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
- TAS2R2 AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ESR1
- ESR2
- MLNR
- MMP9
- MPHOSPH8
- NPSR1
- NPY1R
- NPY2R
- ACHE
- NR3C1
- OPRD1
- OPRK1
- OPRM1
- PDE3A
- PDE4D
- PDE5A
- MMP1
- MC5R
- HTR2B
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KCNH2
- HTR6
- HTR3A
- PGR
- PLAUR
- POLI
- SLCO1B1
- VDR
- USP1
- UGT1A9
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- CP2CJ
- CP3A4
- CP3A7
- ESRRA
- HLAB
- IFNB1
- ITA4
- MCL1
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- M02A · TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
- ANTIINFLAMMATORY/ANTIRHEUMATIC AGENTS IN COMBINATION
Cross-references
Synonyms
- AZOLID
- BUTAZOLIDIN
- Equi-Phar
- Equizone
- Pributazone
- Vetribute
- phenylbutazon
- Fenilbutazona
- Ambene
- Artrizin
- Bizolin
- Butadion
- Butadiona
- Butapirazol
- Butatron
- Butoz
- Buzon
- Diphebuzol
- Ecobutazone
- Equipalazone
- Exrheudon n
- Fenibutazona
- Fenibutol
- Fenylbutazon
- Flexazone
- Intrabutazone
- Intrazone
- Mepha-butazon
- Phebuzine
- Phenyzene
- Robizone-v
- Shigrodin
- Tevcodyne
- Uzone
- Zolaphen
- G-13871
- NSC-25134
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