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WORTMANNIN
SynDRA canonical compound SYN0000636 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | PLK1 |
|---|
| Mechanism of action | PI3K inhibitor |
|---|
All known targets
- PIK3CG
- PIK3CA
- PIK3CD
- MTOR
- PI4KA
- PI4KB
- PLK1
- PRKDC
- ATM
- ATR
- PIK3CB
- PIK3R1
Mechanisms of action (all sources)
- PI3K inhibitor
- MTOR inhibitor
- PIK3CA INHIBITOR
- PIK3CB INHIBITOR
- PIK3CD INHIBITOR
- PIK3CG INHIBITOR
- PI4KA INHIBITOR
- PI4KB INHIBITOR
- PRKDC INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- MYLK
- PIK3CB
- PIK3C3
- PLK2
- ABCB11
- PAK6
- PIN1
- PIM3
- PIM2
- PIM1
- PI4K2A
- PDPK1
- PDK1
- PAK5
- PAK4
- NFE2L2
- NEK7
- NEK6
- NEK2
- MYLK2
- MKNK2
- MKNK1
- MELK
- PKN2
- POLI
- MAPT
- PRKACA
- VDR
- TRPM2
- THRB
- TDP1
- TARDBP
- STK3
- SRPK1
- SNCA
- SMAD3
- SGK1
- RPS6KB1
- RPS6KA5
- RPS6KA3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- EPAS1
- HNF4A
- HS90A
- IL1B
- MDR1
- PIK3R5
- PK3CA
- PLIN5
- STK33
- THB
Drug classes
- Antifungal Agents
- Immunosuppressive Agents
- Insulin Antagonists
- Protein Kinase Inhibitors
- Radiation-Sensitizing Agents
Cross-references
Synonyms
- Wartmannin
- KY 12420
- Antibiotic SL-2052
- SL-2052
- UNII-XVA4O219QW
- NSC221019
- XVA4O219QW
- MLS002703028
- CHEMBL428496
- CHEBI:52289
- Wortmannin, 98%
- Pi 3-Kinase Inhibitor
- NSC 627609
- BRN 0067676
- (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
- NSC627609
- MS54
- MS-54
- RefChem:389363
- DTXCID6020642
- KY-12420
- MFCD00133927
- wortmanin
- Wortmannin?
- Wortmannin, Wm
- SL-2052;KY-12420
- nchembio866-comp1
- WORTMANNIN [MI]
- (+)-WORTMANNIN
- SCHEMBL4531
- BSPBio_001232
- 4-19-00-03134 (Beilstein Handbook Reference)
- cid_312145
- GTPL6060
- MEGxm0_000446
- orb1300904
- orb3024939
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