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PROPOFOL
SynDRA canonical compound SYN0000632 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRQ |
|---|
| Mechanism of action | GABA receptor agonist |
|---|
| Indication | anesthetic |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- GABRG2
- GABRA1
- GABRA2
- GABRB2
- GABRB3
- GABRD
- GABRE
- GABRQ
- GABRP
- GABRG3
- GABRG1
- GABRA3
Mechanisms of action (all sources)
- GABA receptor agonist
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA4 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 POSITIVE ALLOSTERIC MODULATOR
- GABRQ POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRP POSITIVE ALLOSTERIC MODULATOR
- GABRD POSITIVE ALLOSTERIC MODULATOR
- GABRG1 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- ACHE
- MC4R
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC3R
- HRH2
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KCNH2
- HTR6
- HTR3A
- HTR2A
- HTR1A
- PDE4D
- PDE5A
- PGR
- POLI
- USP1
- UGT2B7
- UGT2B15
- UGT1A9
- UGT1A8
- UGT1A6
- UGT1A3
- UGT1A10
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CASP3
- CASP7
- CP1A2
- CP2C9
- CP2CJ
- CP3A7
- GLSK
Drug classes
- General Anesthetic
- Anesthetics
- Anesthetics, Intravenous
- Central Nervous System Agents
- Central Nervous System Depressants
- Hypnotics and Sedatives
ATC classes
- N01A · ANESTHETICS, GENERAL
Cross-references
Synonyms
- DIPRIVAN
- Diprivan
- Propoflo
- Propovan
- Propoven
- ampofol
- diprivan
- disoprofol
- pofol
- Disoprofol
- Fresofol
- Lipuro
- Phenol, 2,6-bis(1-methylethyl)
- ICI 35,868
- ICI 35-868
- ICI-35868
- ICI35,868
- NSC-5105
- Disoprivan
- Propofol component of ketafol
- Rapinovet
- Ampofol
- Aquafol
- Diisopropylphenol
- Dipravan
- Ivofol
- PFL
- Propofolum
- Recofol
- Abbott Brand of Propofol
- Alpha Brand of Propofol
- Astra Brand of Propofol
- AstraZeneca Brand of Propofol
- Braun Brand of Propofol
- Curamed Brand of Propofol
- Diprivan Injectable emulsion
- Fresenius Brand of Propofol
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