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VORINOSTAT
SynDRA canonical compound SYN0000606 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx |
|---|
| Primary target(s) | HDAC3 |
|---|
| Mechanism of action | HDAC inhibitor |
|---|
| Indication | cutaneous T-cell lymphoma (CTCL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- HDAC1
- HDAC2
- HDAC3
- HDAC6
- HDAC8
- HDAC10
- HDAC11
- HDAC5
- HDAC9
- BRD4
- NCOR2
- LTA4H
Mechanisms of action (all sources)
- histone deacetylase inhibitor
- HDAC1 INHIBITOR
- Histone deacetylase 1 inhibitor
- HDAC3 INHIBITOR
- Histone deacetylase 3 inhibitor
- HDAC6 INHIBITOR
- Histone deacetylase 6 inhibitor
- HDAC2 INHIBITOR
- Histone deacetylase 2 inhibitor
- HDAC10 INHIBITOR
- HDAC11 INHIBITOR
- HDAC5 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- MDM2
- TP53
- CFTR
- NR1I2
- PLK1
- NAMPT
- MET
- MLNR
- MMP12
- MMP2
- MMP9
- NFE2L2
- MC4R
- NPY1R
- NPY2R
- NR0B1
- NR3C1
- OPRD1
- MCL1
- ABL1
- OPRM1
- JAK1
- HTR2C
- HTR3A
- HTR6
- HTR7
- IDO1
- IMPDH1
- IMPDH2
- JAK2
- MC3R
- JAK3
- KAT8
- KDM1A
- KDR
- KMT2A
- MAOA
- MAOB
- OPRK1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- ATAD5
- RCOR3
- RARA
- PRGR
- NSD2
- NF2L2
- MITF
- MDR1
- MDM4
- KSYK
- IFNG
- IFNB1
- HTT
- HLAB
- HDA11
- HDA10
- GLI3
- GEMI
- GCR
- FXN
- ESRRA
- CP2D6
- CP2CJ
- CP1A2
- CASP7
- CASP3
- SYK
Drug classes
- Histone Deacetylase Inhibitors
- Histone Deacetylase Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- ZOLINZA
- Zolinza
- suberoylanilide hydroxamic acid
- Suberoylanilide hydroxamic acid
- MK-0683
- MK0683
- NSC-701852
- NSC-748799
- NSC-759852
- NHNPODA
- SAHA
- SHH
- Merck brand of Vorinostat
- OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
- SAHA cpd
- Suberanilohydroxamic acid
- Vorinostat MSD
- Vorinostat [USAN]
- M344
- SKI390
- WIN64652
- SAHA, Suberoylanilide hydroxamic acid
- SW-064652
- Zolinza (TN)
- Vorinostat (JAN/USAN)
- N1-hydroxy-N8-phenyloctanediamide
- Zolinza, MK-0683, SAHA
- N'-hydroxy-N-phenyloctanediamide
- N-Hydroxy-N'-phenyl octanediamide
- N-Hyrdroxy-N'-phenyloctanediamide
- N-hydroxy-N'-phenyloctanediamide
- N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide
- Vorinostat (HDAC inhibitor)
- MK 0683
- Octanediamide, N-hydroxy-N'-phenyl-
- Vorinostat (SAHA, MK0683)
- Vorinostat (SAHA)
- CCRIS 8456
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