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SANGUINARIUM
SynDRA canonical compound SYN0000599 — structure-anchored drug synonym record
| Clinical phase | Phase 1 |
|---|
| Primary target(s) | CASP3 |
|---|
| Mechanism of action | Rho associated kinase inhibitor |
|---|
All known targets
- CASP3
- ACHE
- ATP1A1
- ATP1A2
- ATP1A3
- ATP1B1
- ATP1B2
- ATP1B3
- RGS17
Mechanisms of action (all sources)
- FtsZ inhibitor
- Caspase activator
- Apoptosis stimulant
- Acetylcholinesterase inhibitor
- Rho associated kinase inhibitor
- RGS17 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- BCHE
- RAC1
- TRPA1
- NPSR1
- RAB9A
- POLI
- POLH
- POLB
- PMP22
- PKM
- ABCC2
- RGS4
- NPC1
- NFKB1
- NFE2L2
- MTOR
- MPHOSPH8
- MBNL1
- MAPT
- RGS12
- SAMHD1
- LMNA
- THPO
- USP2
- USP1
- TSHR
- TSG101
- TRPV1
- TP53
- TDP1
- SLCO1B1
- STAT6
- SNCA
- SMN1
- SMAD3
- SLCO2B1
- SLCO1B3
- MAPK1
- KMT2A
- ALDH1A1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ADRB2
- KPYM
- KSYK
- LOX12
- LOX15
- MK01
- NCOA2
- NF2L2
- NFKB2
- NNMT
- NPR1
- NPR2
- NSD2
- NTM1A
- PA2G3
- PAX8
- PE2R2
- PNMT
- PPARD
- PRGR
- PRIO
- PRMT1
- RARA
- RELA
- SIAE
- SYK
- IFNB1
- IDHC
- HSPB1
- CP3A7
- AHR
- ANDR
- CASP7
- CIB1
- COMT
- COT2
- CP19A
- CP1A2
- CP2CJ
Drug classes
- Anti-Infective Agents
- Cardiotonic Agents
Cross-references
Synonyms
- Sanguinarine
- Pseudochelerythrine
- Sangrovit
- Sanguinarin
- sangvinarin
- Veadent
- Sanguiritrin
- Dimethylenedioxy benzphenanthridine
- UNII-AV9VK043SS
- C20H14NO4
- EINECS 219-503-3
- Benzophenanthridine alkaloid
- BRN 3915507
- AV9VK043SS
- CHEBI:17183
- NCGC00015959-03
- CAS-2447-54-3
- [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium, 13-methyl-
- DSSTox_RID_80748
- DSSTox_CID_25204
- DSSTox_GSID_45204
- 13-Methyl[1,3]benzodioxolo[5,6-C][1,3]dioxolo[4,5-I]phenanthridin-13-Ium
- y-Chelerythrine
- SR-01000075650
- sanguinarium-chloride
- DTXCID8025204
- pseudo-chelerythrine
- RefChem:48744
- Pseudochelerythrine;Sanguinarin
- Dimethylenedioxybenzphenanthridine
- UI5
- Sanguinarium Chloride
- Spectrum_000259
- Prestwick0_000987
- Prestwick1_000987
- Prestwick2_000987
- Prestwick3_000987
- Spectrum2_000724
- Spectrum3_001148
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