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DISOPYRAMIDE
SynDRA canonical compound SYN0000597 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SCN5A |
|---|
| Mechanism of action | Sodium channel blocker |
|---|
| Indication | ventricular arrhythmias | ventricular tachycardia (VT) |
|---|
| Disease area | cardiology |
|---|
All known targets
- SCN5A
- KCNH2
- CHRM1
- SCN1A
- SCN9A
- SCN8A
- SCN7A
- SCN4A
- SCN3A
- SCN2A
- SCN11A
- CHRM2
Mechanisms of action (all sources)
- Sodium channel blocker
- SCN1A BLOCKER
- Sodium channel alpha subunit blocker
- SCN5A BLOCKER
- SCN4A BLOCKER
- SCN7A BLOCKER
- SCN2A BLOCKER
- SCN9A BLOCKER
- SCN3A BLOCKER
- SCN11A BLOCKER
- SCN8A BLOCKER
- SCN10A BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- DRD2
- SLC22A2
- ADRB3
- PDE3A
- ABCB1
- NPY1R
- OPRD1
- NTSR1
- NR3C1
- NR1I2
- NPY2R
- MLNR
- MC4R
- MC3R
- MAOA
- KAT2A
- IDH1
- HTR3A
- HTR2C
- HTR2B
- OPRM1
- PGR
- PDE4D
- HTR1A
- TBXA2R
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC47A2
- SLC47A1
- SLC29A1
- SAMHD1
- RGS4
- PTGS2
- PPARG
- POLK
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antiarrhythmic
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Sodium Channel Blockers
- Voltage-Gated Sodium Channel Blockers
ATC classes
- C01B · ANTIARRHYTHMICS, CLASS I AND III
Cross-references
Synonyms
- DISOPYRAMIDE PHOSPHATE
- NORPACE
- NORPACE CR
- Norpace
- dicorantil
- disopyramide phosphate
- disopyramide tartrate
- disopyramide monohydrochloride
- disopyramide hydrochloride
- Disopiramida
- (rs)-disopyramide
- Dicorantil
- Dl-disopyramide
- Isorythm
- Lispine
- Ritmilen
- Rythmodan p
- Searle-703
- H-3292
- SC-7031
- Disopyramidum
- Ritmodan
- Rythmodan
- Disopyramide Free Base
- Rythmodan P
- D 7644
- H 3292
- Searle 703
- Disopiramida [INN-Spanish]
- Disopyramidum [INN-Latin]
- Norpace (TN)
- Rythmodan (TN)
- Rythmodan P (TN)
- Rythmodan-La
- Xi-Disopyramide
- Disopyramide (JP15/USAN/INN)
- Disopyramide [USAN:BAN:INN:JAN]
- Alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide
Reported adverse events
- Depression
- Urinary retention
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