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CHLORAMBUCIL
SynDRA canonical compound SYN0000589 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Mechanism of action | DNA inhibitor |
|---|
| Indication | chronic lymphocytic leukemia (CLL) | Hodgkin's lymphoma |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- ADAM9
- Akr1b1
- CTSD
- CTSE
- OPRD1
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- MAPK1
- NPY2R
- NPY1R
- NFKB1
- NFE2L2
- MMP9
- MMP1
- MDH1
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK3
- MAPK14
- MAOA
- OPRK1
- LMNA
- LCK
- KDR
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HIF1A
- NR3C1
- OPRM1
- GSTP1
- SLC6A2
- VDR
- TSHR
- TP53
- THPO
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALR
- ATAD5
- CASP3
- CASP7
- ESRRA
- NF2L2
- STK33
Drug classes
- Alkylating Activity
- Alkylating Drug
- Alkylating Agents
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Noxae
ATC classes
Cross-references
Synonyms
- LEUKERAN
- Leukeran
- ambochlorin
- amboclorin
- chloraminophene
- chlorbutin
- chlorobutine
- Clorambucilo
- Ambochlorin
- Chlorambucilum
- Ecloril
- Lympholysin
- CB-1348
- NCI-3088
- NSC-3088
- Amboclorin
- Chlocambucil
- Chloorambucol
- Chloraminophen
- Chloraminophene
- Chlorbutin
- Chlorbutine
- Chlorbutinum
- Chloroambucil
- Chlorobutin
- Chlorobutine
- Clorambucile
- Elcoril
- Elcorin
- Leukersan
- Leukoran
- Linfolizin
- Linfolysin
- Clorambucile [DCIT]
- Glaxo Wellcome Brand of Chlorambucil
- GlaxoSmithKline Brand of Chlorambucil
- Leuk ersan
- Leukeran tablets
Reported adverse events
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