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CHLORPHENIRAMINE
SynDRA canonical compound SYN0000546 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH1 |
|---|
| Mechanism of action | histamine receptor antagonist |
|---|
| Indication | allergic rhinitis | urticaria |
|---|
| Disease area | allergy |
|---|
All known targets
- HRH1
- CRT
- CYP2D6
- HRH4
- HTR2B
- Hrh1
- KCNH2
- L3MBTL1
- L3MBTL3
- MBTD1
- SCN1A
- SCN2A
Mechanisms of action (all sources)
- HRH1 ANTAGONIST
- Histamine H1 receptor antagonist
- histamine receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CHRM5
- HTR2A
- ADRA1A
- HRH2
- ADRA2B
- CHRM2
- CHRM1
- ESR1
- ABCB1
- MC4R
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- MLNR
- LMNA
- MC3R
- MAOA
- OPRD1
- L3MBTL4
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR1A
- NTSR1
- OPRM1
- OPRK1
- PDE3A
- UGT1A6
- UGT1A4
- TBXA2R
- TACR2
- TACR1
- SMAD3
- SLC29A1
- SCN5A
- SAMHD1
- PTGS2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- CP2CJ
- CP2D6
- ESRRA
- GLI3
- JUN
- KCMB1
- MDR1
- NR1I2
Drug classes
- Histamine H1 Receptor Antagonists
- Histamine-1 Receptor Antagonist
- Anti-Allergic Agents
- Antipruritics
- Dermatologic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Neurotransmitter Agents
ATC classes
- R06A · ANTIHISTAMINES FOR SYSTEMIC USE
Cross-references
Synonyms
- ADVIL ALLERGY AND CONGESTION RELIEF
- ADVIL ALLERGY SINUS
- ADVIL MULTI-SYMPTOM COLD & FLU
- ANTAGONATE
- Aller-Chlor
- CHILDREN'S ADVIL ALLERGY SINUS
- CHLOR-TRIMETON
- CHLORPHENIRAMINE MALEATE
- CODEPREX
- CODIMAL-L.A. 12
- COLD CAPSULE IV
- COLD CAPSULE V
- chlorphenamine
- chloropheniramine
- chlorophenylpyridamine
- chloroprophenpyridamine
- chlorprophenpyridamine
- chlorpheniramine maleate
- chlorpheniramine tannate
- chlorpheniramine polistirex
- Chlorphenamine
- Clorfenamina
- Isoclor
- Allergican
- Allergisan
- Antagonate
- Chloropheniramine
- Chlorophenylpyridamin
- Chlorophenylpyridamine
- Chloropiril
- Chloroprophenpyridamine
- Chlorphenaminum
- Chlorpheniraminum
- Chlorprophenpyridamine
- Clofeniramina
- Clorfeniramina
- Cloropiril
- Haynon
Reported adverse events
- Urinary retention
- Hypotension
- Nervousness
- Sedation
- Urticaria
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