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DONEPEZIL
SynDRA canonical compound SYN0000507 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ACHE |
|---|
| Mechanism of action | Acetylcholinesterase inhibitor |
|---|
| Indication | Alzheimer's disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ACHE
- ABCB1
- Ache
- BACE1
- BCHE
- Bche
- CHRNE
- Chat
- HRH3
- KCNH2
- MAOB
- Maob
Mechanisms of action (all sources)
- Acetylcholinesterase inhibitor
- ACHE INHIBITOR
- ACHE MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2B
- SLC6A2
- CHRM2
- CHRM1
- DRD4
- PDE5A
- ESR1
- ADRB2
- MARK4
- ADRA2C
- FAAH
- ADRA1A
- SLC6A3
- HTR6
- MAPT
- MAOA
- KDR
- KDM4E
- GSK3B
- HTR7
- HTR3A
- HTR4
- HDAC6
- HTR2C
- MC3R
- HTR2A
- HTR1A
- HRH2
- HRH1
- ABCB11
- NR3C1
- MC4R
- MLNR
- TDP1
- TBXA2R
- TACR1
- SMPD1
- SLC29A1
- SCN5A
- PTH1R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- CP2D6
- GLI3
- NSD2
- TOR1A
Drug classes
- Cholinesterase Inhibitors
- Central Nervous System Agents
- Cholinergic Agents
- Enzyme Inhibitors
- Neurotransmitter Agents
- Nootropic Agents
- Cholinesterase Inhibitor
ATC classes
- N06D · ANTI-DEMENTIA DRUGS
Cross-references
Synonyms
- ADLARITY
- ARICEPT
- ARICEPT ODT
- Adlarity
- Aricept
- DONEPEZIL HYDROCHLORIDE
- MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE
- NAMZARIC
- Namzaric
- aricept
- donepezil hydrochloride
- donepezil HCl
- donezpil hydrochloride
- donezpil
- donezpil HCl
- donepezilium oxalate trihydrate
- donepezilium oxalate
- donepezil oxalate
- E2020
- E-2020
- Donepezilo
- D-797
- Donaz
- Donepezil (transdermal patch, Alzheimer's disease)
- D797
- 8SSC91326P
- donepezilo
- donepezilum
- Domepezil
- CHEBI:53289
- donepezil hydrochlorid
- RefChem:5777
- DTXCID0028292
- N06DA02
- C24H29NO3
- MFCD00912833
- Donepezil [INN:BAN]
- HSDB 7743
Reported adverse events
- Headache
- Syncope
- Vomiting
- Hallucination
- Abdominal pain
- Weight
- Fatigue
- Dizziness
- Insomnia
- Nausea
- Seizure
- Arthritis
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