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TACRINE
SynDRA canonical compound SYN0000505 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | BCHE |
|---|
| Mechanism of action | Acetylcholinesterase inhibitor |
|---|
| Indication | Alzheimer's disease |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- ACHE
- BCHE
- Chrm3
- SLC6A2
- SLC22A1
- Maoa
- MAOA
- KCNH2
- Hnmt
- GRIN2B
- GRIN2A
- GRIN1
Mechanisms of action (all sources)
- Acetylcholinesterase inhibitor
- BCHE INHIBITOR
- ACHE INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- FTO
- SLC22A2
- SLC47A1
- CYP1A2
- ESR1
- MC3R
- MAOB
- MAPK1
- MAPK14
- MAPK3
- MAPT
- MC4R
- LCK
- MC5R
- MDH1
- MMP1
- MMP9
- NFE2L2
- NFKB1
- LMNA
- KDM4E
- KDR
- NPY1R
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSD17B10
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GSK3B
- GMNN
- NOS1
- ABCB1
- FYN
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AHR
- LOX15
- SYK
- SC5A7
- PNMT
- NR1I2
- NNMT
- NF2L2
- MDR1
- MCL1
- KSYK
- CFTR
- GNMT
- GLI3
- GAMT
- ESRRA
- CP2D6
- CP2CJ
- CP1A2
- COMT
- TP53
Drug classes
- Cholinesterase Inhibitors
- Central Nervous System Agents
- Cholinergic Agents
- Enzyme Inhibitors
- Neurotransmitter Agents
- Nootropic Agents
- Parasympathomimetics
- Peripheral Nervous System Agents
- Cholinesterase Inhibitor
ATC classes
- N06D · ANTI-DEMENTIA DRUGS
Cross-references
Synonyms
- COGNEX
- tacrine hydrochloride
- tetrahydroaminacrine
- tetrahydroaminoacridine
- tetrahydroaminocrin
- tetrahydroaminocrine
- cognex
- tacrine HCl
- Tacrina
- Tacrinal
- Cognex
- Romotal
- Tacrinum
- Tenakrin
- Tetrahydroaminacrine
- Tetrahydroaminoacridine
- Tetrahydroaminocrin
- Tetrahydroaminocrine
- Tha
- Tacrine hydrochloride
- BBL001044
- CS 12602
- Cognex (TN)
- Tacrina [INN-Spanish]
- Tacrinal (TN)
- Tacrine (INN)
- Tacrine [INN:BAN]
- Tacrinum [INN-Latin]
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE
- 1,2,3,4-TETRAHYDRO-9-ACRIDINAMINE (SEE ALSO 1684-40-8)
- 1,2,3,4-Tetrahydro-9-acridineamine
- 1,2,3,4-Tetrahydro-acridin-9-ylamine
- 1,2,3,4-Tetrahydroaminoacridine
- 1,2,3,4-tetrahydroacridin-9-amine
- 5-Amino-6,7,8,9-tetrahydroacridine (European)
- 9-AMINOTETRAHYDROACRIDINE
- 9-Acridinamine, 1,2,3,4-tetrahydro-(9CI)
- 9-amino-1,2,3,4-tetrahydroacridine
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