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ZILEUTON
SynDRA canonical compound SYN0000501 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ALOX5 |
|---|
| Mechanism of action | Lipoxygenase inhibitor |
|---|
| Indication | asthma |
|---|
| Disease area | pulmonary |
|---|
All known targets
- ALOX5
- ALOX15
- ALOX5AP
- Alox5
- CYSLTR2
- EPHX2
- LTA4H
- LTB4R
- PTGES
Mechanisms of action (all sources)
- Leukotriene inhibitor
- Lipoxygenase inhibitor
- ALOX5 INHIBITOR
- Arachidonate 5-lipoxygenase inhibitor
- leukotriene synthesis inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- LOX
- ACHE
- MAOA
- MMP9
- MMP2
- MMP12
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOB
- LTC4S
- MTARC2
- LMNA
- LCK
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- MTARC1
- NPY1R
- ADORA1
- PTPRC
- TRPV1
- TF
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2C9
- CP2CJ
- CP3A4
- CP3A7
- PPARG
Drug classes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Hormone Antagonists
- Leukotriene Antagonists
- Lipoxygenase Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
- 5-Lipoxygenase Inhibitors
Cross-references
Synonyms
- ZYFLO
- ZYFLO CR
- Zyflo
- leutrol
- A 64077
- A-64077
- ABBOTT-64077
- NSC-730712
- NSC-759277
- Zyflo cr
- Leutrol
- Zileutonum
- Ziluton
- Abbott brand of zileuton
- Zyflo CR
- Zyflo Filmtab
- Abbot 64077
- ABT-077
- CTI-02
- ZYFLO (TN)
- ZYFLO, Zileuton
- Zileutonum [INN-Latin]
- Zileuton (USP/INN)
- Zileuton [USAN:INN:BAN]
- N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea
- N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea
- NSC 730712
- zileuton (usp monograph)
- Urea, N-(1-benzo(b)thien-2-ylethyl)-N-hydroxy-, (+-)-
- Abbott 64077
- NSC 759277
- zileuton (usp-rs)
- V1L22WVE2S
- DTXCID003752
- CHEBI:10112
- NSC730712
- N-(1-(benzo(b)thiophen-2-yl)ethyl)-N-hydroxyurea
Reported adverse events
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