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HYDRALAZINE
SynDRA canonical compound SYN0000484 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | MPO |
|---|
| Mechanism of action | myeloperoxidase inhibitor | vasodilator |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- MPO
- ALOX15
- AOC3
- AOX1
- BCHE
- CACNA1C
- DNMT1
- DNMT3A
- DNMT3B
- GOT1
- LPO
- RYR2
Mechanisms of action (all sources)
- myeloperoxidase inhibitor
- AOC3 MODULATOR
- RYR2 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACOX1
- PTGS1
- OPRD1
- NTHL1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- NPC1
- NFE2L2
- NEIL1
- MMP9
- MMP1
- MDH1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KDM4E
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- OGG1
- OPRK1
- HRH3
- SLC22A1
- TP53
- THPO
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- AICDA
- CP1A2
- HTT
- KPYM
- SMN
- TPO
Drug classes
- Arteriolar Vasodilator
- Antihypertensive Agents
- Cardiovascular Agents
- Vasodilator Agents
- vasodilator
ATC classes
- C02D · ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
- ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION
Cross-references
Synonyms
- APRESAZIDE
- APRESOLINE
- APRESOLINE-ESIDRIX
- BIDIL
- CAM-AP-ES
- DRALSERP
- DRALZINE
- HYDRA-ZIDE
- HYDRALAZINE AND HYDROCHLOROTHIAZIDE
- HYDRALAZINE HYDROCHLORIDE
- HYDRALAZINE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE
- HYDRALAZINE HYDROCHLORIDE W/ HYDROCHLOROTHIAZIDE 100/50
- hydralazine hydrochloride
- hydralazine HCl
- Hidralazina
- NSC-126699
- Hydralazine polistirex
- Apresolin
- Apresoline
- Apressin
- Apressoline
- Aprezolin
- HLZ
- Hidral
- Hidralazin
- Hipoftalin
- Hydralazin
- Hydralazinum
- Hydrallazin
- Hydrallazine
- Hydrazinophthalazine
- Hypophthalin
- Idralazina
- Hidralazina [Spanish]
- Idralazina [DCIT]
- Idralazina [Italian]
- BA 5968
- C-5968
Reported adverse events
- Headache
- Hypersensitivity
- Dizziness
- Abdominal discomfort
- Amblyopia
- Asthenia
- Chromaturia
- Dysgeusia
- Erythema
- Facial pain
- Hepatitis
- Hypotension
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