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TIMOLOL
SynDRA canonical compound SYN0000474 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRB2 |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | glaucoma | ocular hypertension |
|---|
| Disease area | ophthalmology |
|---|
All known targets
- ADRB1
- ADRB2
- ADRB3
- Adrb2
- HTR1A
- Htr1a
Mechanisms of action (all sources)
- Adrenergic receptor antagonist
- ADRB1 ANTAGONIST
- Beta-1 adrenergic receptor antagonist
- ADRB2 ANTAGONIST
- Beta-2 adrenergic receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SIGMAR1
- NPY2R
- NPY1R
- DRD1
- ABCB1
- MUTYH
- MC5R
- MLNR
- MMP1
- MMP9
- NEIL1
- MC3R
- NEIL2
- NFKB1
- NR1I2
- NR3C1
- NTHL1
- MC4R
- MBD4
- OPRD1
- MAPK3
- HRH4
- HTR1B
- HTR1D
- HTR1E
- HTR2A
- HTR2B
- HTR2C
- HTR3A
- HTR6
- KCNH2
- LCK
- MAOA
- MAOB
- MAPK1
- MAPK14
- OGG1
- OPRK1
- HRH2
- OPRM1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Adrenergic Agents
- Adrenergic Antagonists
- Adrenergic beta-Antagonists
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
ATC classes
- C07A · BETA BLOCKING AGENTS
- S01E · ANTIGLAUCOMA PREPARATIONS AND MIOTICS
- BETA BLOCKING AGENTS AND THIAZIDES
- BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS
Cross-references
Synonyms
- BETIMOL
- BLOCADREN
- BRIMONIDINE TARTRATE AND TIMOLOL MALEATE
- Betimol
- COMBIGAN
- COSOPT
- COSOPT PF
- Combigan
- Cosopt
- DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE
- ISTALOL
- Istalol
- timolol maleate
- (-)-Timolol
- (S)-Timolol
- arutimol
- L-Timolol
- timolol maleate salt
- Timolol anhydrous
- Timolol hemihydrate
- Betim
- Blocadren
- Glau-opt
- Glaucol
- Nyogel
- Tiopex
- Aquanil
- Optimol
- Proflax
- TIM
- Temserin
- Tenopt
- Timacar
- Timololum
- Timopic
- Timoptol
- Timolol GFS
- Timolol [USAN]
Reported adverse events
- Bronchospasm
- Arthralgia
- Gastrointestinal pain
- Raynaud's phenomenon
- Vertigo
- Asthenia
- Pruritus
- Rales
- Hypersensitivity
- Arrhythmia
- Systemic lupus erythematosus
- Alopecia
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