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ALPROSTADIL
SynDRA canonical compound SYN0000465 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGER2 |
|---|
| Mechanism of action | Prostanoid receptor agonist |
|---|
| Indication | congenital heart defects |
|---|
| Disease area | cardiology |
|---|
All known targets
- PTGER2
- PTGER1
- CATSPER1
- CATSPER3
- CATSPER4
- PTGDR
- CATSPER2
- PTGER4
- PTGIR
- Ptger3
- Ptgir
- Ptger4
Mechanisms of action (all sources)
- Prostanoid receptor agonist
- PTGER1 AGONIST
- Prostanoid EP1 receptor agonist
- PTGER2 AGONIST
- Prostanoid EP2 receptor agonist
- TBXA2R MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC4
- SLCO3A1
- SLCO2A1
- DRD1
- MLNR
- NR1I3
- NR1I2
- NR1H4
- NR1H3
- NR1H2
- NPY1R
- NEIL1
- MUTYH
- MPG
- MC4R
- NTHL1
- MC3R
- MBD4
- MAPK1
- MAOA
- KCNH2
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- NR3C1
- ABCC3
- HTR1A
- S1PR1
- TRIM24
- TDP1
- TDG
- SMUG1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- RARG
- OPRD1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CTSR1
- CTSR2
- CTSR4
- MRGPRX1
- NSD2
- PD2R
- PE2R4
- PI2R
- RAPGEF4
- RGS4
- RPGF4
Drug classes
- Prostaglandin Receptor Agonists
- Prostaglandin Analog
- Cardiovascular Agents
- Hematologic Agents
- Platelet Aggregation Inhibitors
- Urological Agents
- Vasodilator Agents
- Prostaglandin E1 Agonist
ATC classes
- G04B · UROLOGICALS
- C01E · OTHER CARDIAC PREPARATIONS
Cross-references
Synonyms
- CAVERJECT
- CAVERJECT IMPULSE
- Caverject
- EDEX
- Edex
- MUSE
- Muse
- PROSTIN VR PEDIATRIC
- Prostin VR
- prostaglandin E1
- vasaprostan
- PGE1
- prostavasin
- alprostadil alfadex
- tandetoron
- Prostaglandin e1
- Pge1
- NSC-165559
- ONO-1608
- U-10,136
- U-10136
- Caverject impulse
- Prostin vr
- Prostin vr pediatric
- Viridal 10
- Viridal 20
- Viridal 5
- Viridal duo
- Vitaros
- Prostaglandin E1
- Alprostadilum
- Femprox
- Befar
- Prostandin
- Liprostin
- PGE-1
- Prink (TN)
Reported adverse events
- Ecchymosis
- Penile pain
- Penis disorder
- Priapism
- Penile rash
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