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METOCLOPRAMIDE
SynDRA canonical compound SYN0000458 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR4 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | gastroparesis | nausea | vomiting |
|---|
| Disease area | gastroenterology |
|---|
All known targets
- HTR3A
- DRD2
- HTR4
- HTR3B
- CHRM1
- Htr3b
- Htr3a
- Htr2c
- Htr2b
- HTR3C
- Htr4
- Htr1f
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR3A ANTAGONIST
- Serotonin 3a (5-HT3a) receptor antagonist
- HTR4 AGONIST
- Serotonin 4 (5-HT4) receptor agonist
- HTR3B ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD4
- ACHE
- ESR2
- KCNH2
- MAPK14
- NPY2R
- NPY1R
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- ABCB1
- MAPK1
- NTSR1
- MAOA
- LMNA
- LCK
- HTR6
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NR3C1
- OPRD1
- GIPR
- OPRK1
- TTR
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Antiemetics
- Central Nervous System Agents
- Dopamine Agents
- Dopamine Antagonists
- Dopamine D2 Receptor Antagonists
- Gastrointestinal Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Dopamine D2 Antagonists
- Dopamine-2 Receptor Antagonist
ATC classes
Cross-references
Synonyms
- CLOPRA
- CLOPRA-"YELLOW"
- GIMOTI
- Gimoti
- MAXOLON
- METOCLOPRAMIDE HYDROCHLORIDE
- METOCLOPRAMIDE INTENSOL
- METOZOLV ODT
- Metozolv
- REGLAN
- REGLAN ODT
- metoclopramide hydrochloride
- metochlopramide
- methochlopramide
- metoclopramide hydrochloride hydrate
- metoclopramide monohydrochloride
- metoclopramide HCl
- AHR-3070-C
- metaclopramide
- Metoclopramida
- Clopra-"yellow"
- Elieten
- Methoxyclopramide
- Terperan
- Cerucal
- Clopra
- Clopromate
- Duraclamid
- Emetid
- Emitasol
- Emperal
- Eucil
- Gastrese
- Gastrobid
- Gastromax
- Gastronerton
- Gastrosil
Reported adverse events
- Tardive dyskinesia
- Fluid retention
- Insomnia
- Restlessness
- Depression
- Hallucination
- Hypersensitivity
- Hypertension
- Agranulocytosis
- Bronchospasm
- Hepatotoxicity
- Neuroleptic malignant syndrome
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