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RISPERIDONE
SynDRA canonical compound SYN0000455 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2C |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | bipolar disorder | irritability | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2A
- HTR2C
- HTR1D
- HTR1A
- ADRA1B
- HRH1
- DRD3
- ADRA1A
- HTR1F
- HTR1E
- ADRA1D
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR1A ANTAGONIST
- HTR1B ANTAGONIST
- HTR1D ANTAGONIST
- HTR1E ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CHRM5
- ESR1
- ABCB1
- MLNR
- OPRM1
- OPRK1
- OPRD1
- NTSR1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- MMP9
- MMP1
- MC5R
- PDE4A
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KDM4A
- HTR3A
- PDE3A
- PDE4D
- HDAC6
- PDE5A
- TSHR
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SMAD3
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1B
- 5HT1D
- 5HT1E
- 5HT1F
- 5HT6R
- 5HT7R
- ACES
- ADA1A
- ADA1B
- ADA1D
- CP2D6
- ESRRA
- KCMA1
- NCF1
Drug classes
- Atypical Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- PERSERIS KIT
- Perseris
- RISPERDAL
- RISPERDAL CONSTA
- RISVAN
- RYKINDO
- Risperdal
- Rykindo
- UZEDY
- Uzedy
- ripedon
- rispadal
- risperdal
- risperidal
- R 64,766
- okedi
- Risperidona
- Risvan
- LY-03004
- LY03004
- N05AX08
- NSC-759895
- R-64-766
- R-64,766
- R-64766
- RCN-3028
- RCN3028
- Okedi
- Perseris kit
- Risperdal consta
- Risperdal consta long acting
- Risperdal m
- Risperdal m-tab
- Risperdal quicklet
- Belivon
- Risperdone
- Risperidal
Reported adverse events
- Parkinsonism
- Dystonia
- Weight
- Insomnia
- Dyskinesia
- Dysphagia
- Priapism
- Somnolence
- Syncope
- Agranulocytosis
- Akathisia
- Constipation
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