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TOPOTECAN
SynDRA canonical compound SYN0000450 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TOP1 |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | cervical cancer | small cell lung cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TOP1
- TOP1MT
- ABCB1
- ABCC2
- ABCC4
- ABCG2
- CYP3A4
- HIF1A
- NR1I2
- SLC22A2
- SLC47A1
- SLC47A2
Mechanisms of action (all sources)
- topoisomerase inhibitor
- TOP1 INHIBITOR
- DNA topoisomerase I inhibitor
- TOP1 MODULATOR
- TOP1MT INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- ESR1
- ACHE
- MAPK14
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK1
- OPRM1
- MAOA
- LMNA
- LCK
- KMT2A
- KEAP1
- KDM4E
- KCNH2
- KAT2A
- IDH1
- IDE
- HTR6
- OPRK1
- PAX8
- HTR2B
- PDE5A
- VIPR1
- USP2
- USP1
- TSG101
- TDP1
- TBXAS1
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- RPGF4
- MITF
- NCOA3
- NOD2
- NR1H4
- NR5A2
- NSD2
- PE2R2
- PRMT1
- RARA
- RIPK2
- RPGF3
- SMAD2
- B2CL1
- SYK
- TFE3
- TLR9
- TNNC1
- TNNI3
- TNNT2
- TOP2A
- TOP2B
- TP53
- TRFR
- TS101
- MDM4
- MDM2
- MCL1
- KSYK
- BARD1
- CAC1H
- CASP3
- CCDC88A
- CFTR
- CIB1
- CP19A
- CP3A7
- CREB1
- CRHBP
Drug classes
- Topoisomerase Inhibitors
- Topoisomerase Inhibitor
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase I Inhibitors
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- HYCAMTIN
- Hycamtin
- TOPOTECAN HYDROCHLORIDE
- nogitecan
- potactasol
- nogitecan hydrochloride
- (S)-Topotecan
- hycamptamine
- topotecan lactone
- topotecan hydrochloride
- hycamtin
- nogitecan HCl
- topotecan HCl
- Topotecane
- Ff-10850 (liposomal topotecan)
- Hycamptamine
- Hycamptin
- Nogitecan
- NSC-609699
- NSC-641007
- SK&F-104864
- SKF-104864
- Hycamtamine
- Topotecanum
- Topotecan lactone
- SKF 104864
- SKF-S 104864
- TOPOTECAN, HYCAMTIN
- Topotecan (BAN)
- Topotecan [INN:BAN]
- Topotecane [INN-French]
- Topotecanum [INN-Latin]
- Topotecan Monohydrochloride, (S)-Isomer
- 9-Dimethylaminomethyl-10-hydroxycamptothecin
- Topetecan
- Topotecan Hcl
- Hycamptamine hydrochloride
Reported adverse events
- Fatigue
- Neutropenia
- Thrombocytopenia
- Infection
- Hypersensitivity
- Interstitial lung disease
- Nausea
- Sepsis
- Extravasation
- Asthenia
- Febrile neutropenia
- Vomiting
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