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9-AMINOCAMPTOTHECIN
SynDRA canonical compound SYN0000444 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | TOP1 |
|---|
| Mechanism of action | topoisomerase inhibitor |
|---|
All known targets
Mechanisms of action (all sources)
- TOP1 INHIBITOR
- DNA topoisomerase I inhibitor
- topoisomerase inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCG2
- APEX1
- TDP1
- SMPD1
- SMAD3
- RECQL
- RAB9A
- PTH1R
- POLK
- POLI
- POLH
- POLB
- PIN1
- PAX8
- NR2E3
- NFE2L2
- MBNL1
- MAPT
- KDM4E
- IDH1
- HDAC6
- GNAS
- GMNN
- FEN1
- BLM
- ATXN2
- ATAD5
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- BARD1
- NCOA1
- TNF
- SAE1
- PSIP1
- PABP1
- OXYR
- NR5A2
- NOD2
- NOD1
- NCOA3
- NCOA2
- MITF
- BRCA1
- MDM4
- MDM2
- KLK7
- IL1B
- IF4H
- IDHC
- DPOLB
- CTDS1
- CSTA
- CFTR
- UBA2
Drug classes
Cross-references
Synonyms
- 9-amino-20(s)-camptothecin
- Aminocamptothecin
- NSC-603071
- IDEC-132
- (S)-10-Amino-4-ethyl-4-hydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- 9-Amino-20(S)-camptothecin
- 9-Amino-cpt
- 9-AMINO-20(S)-CAMPTOTHECIN
- NSC 603071
- 5MB77ICE2Q
- RefChem:107746
- DTXCID50820699
- 9-amino-20-camptothecin, (R,S)-
- aminocamptothecin
- 9-amino camptothecin
- 9-Amino-20-(S)-camptothecin
- MFCD00909855
- NSC603071
- Camptothecin, 9-amino-
- MLS002702905
- UNII-5MB77ICE2Q
- NSC-629971
- 9-aminocamptothecan
- 9-NH2-Camptothecin
- Camptothecin Impurity 14
- SCHEMBL26578
- cid_72402
- MLS000728575
- orb1303365
- SCHEMBL29369669
- 9-Aminocamptothecin Hydrochloride
- CHEBI:80755
- 9-AMINOCAMPTOTHECIN [MI]
- HMS2220K11
- HMS3339H11
- HMS3749C03
- EX-A4335
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