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RALOXIFENE
SynDRA canonical compound SYN0000436 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ESR2 |
|---|
| Mechanism of action | Selective estrogen receptor modulator |
|---|
| Indication | breast cancer | osteoporosis |
|---|
| Disease area | oncology | orthopedics |
|---|
All known targets
- ESR1
- ESR2
- GPER1
- AOX1
- NR1I2
- HTR2B
- HTR2C
- HTR6
- Htr1b
- IL6
- KDM1A
- NR1H4
Mechanisms of action (all sources)
- ESR1 ANTAGONIST
- Selective estrogen receptor modulator
- ESR2 MODULATOR
- ESR1 MODULATOR
- AOX1 INHIBITOR
- ESR1 AGONIST
- ESR2 ANTAGONIST
- GPER1 FULL AGONIST
- selective estrogen receptor modulator (SERM)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- CNR1
- KCNH2
- ADRB3
- HRH2
- PDE3A
- CYP3A4
- NPY1R
- MTOR
- NFE2L2
- NFKB1
- NPSR1
- NTSR1
- NPY2R
- NR3C1
- MMP9
- P4HB
- PDE4D
- PDE5A
- MPHOSPH8
- ADORA1
- MMP1
- PIN1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KMT2A
- KDM4A
- IL6ST
- MLNR
- PMP22
- IDH1
- TSHR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- HSPB1
- ITA4
- KCNQ1
- KSYK
- LOX12
- M4K2
- MDM2
- MDM4
- MDR1
- NSD2
- PIP4K2A
- PPP1CA
- PRGR
- RARA
- RGAP1
- SIAE
- SMAD2
- SYK
- IDHC
- GLSK
- ACES
- GLI3
- ACM1
- ALAT2
- ALOX12
- ALR
- ANDR
- APAF
- CASP3
- CASP7
- CP19A
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CREB1
- ESRRA
- GCR
- GEMI
Drug classes
- Selective Estrogen Receptor Modulators
- Estrogen Agonist/Antagonist
- Bone Density Conservation Agents
- Estrogen Antagonists
- Estrogen Receptor Modulators
- Hormone Antagonists
ATC classes
- G03X · OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
Cross-references
Synonyms
- EVISTA
- Evista
- RALOXIFENE HYDROCHLORIDE
- keoxifene
- raloxifene hydrochloride
- evista
- raloxifene HCl
- Raloxifeno
- Eviden
- Keoxifene
- Raloxiphene
- Raxeto
- J22.982B
- LY-139481
- NSC-747974
- Raloxifene (extended-release, CDT)
- Raloxifenum
- Raloxifenum [Latin]
- Raloxifeno [Spanish]
- Pharoxifene
- CHEMBL81
- NSC 747974
- Keoxifene; LY 139481;
- CHEBI:8772
- YX9162EO3I
- Raloxifene (INN)
- LY139481
- RALOXIFENE [INN]
- Raloxifene [INN:BAN]
- CCRIS 7129
- HSDB 7460
- NCGC00015889-05
- CAS-82640-04-8
- UNII-YX9162EO3I
- Raloxifene D4
- Raloxifene, 6
- Eviden (TN)
- Raxeto (TN)
Reported adverse events
- K
- Headache
- Rash
- Nausea
- Arthralgia
- Arthritis
- Bronchitis
- Conjunctivitis
- Cough
- Cystitis
- Depression
- Dyspepsia
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