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NALOXONE
SynDRA canonical compound SYN0000435 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | OPRM1 |
|---|
| Mechanism of action | Opioid receptor antagonist |
|---|
| Indication | respiratory depression |
|---|
| Disease area | pulmonary |
|---|
All known targets
- OPRM1
- OPRD1
- OPRK1
- ADORA3
- CREB1
- CYP2D6
- Ccr5
- ESR1
- Oprd1
- Oprk1
- Oprm1
- Sigmar1
Mechanisms of action (all sources)
- Opioid receptor antagonist
- OPRK1 ANTAGONIST
- Opioid receptors; mu/kappa/delta antagonist
- OPRD1 ANTAGONIST
- OPRM1 ANTAGONIST
- Mu opioid receptor antagonist
- OPRM1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYBB
- ABCB1
- GMNN
- OPRL1
- NR3C1
- NPY2R
- NPY1R
- MRGPRX2
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KISS1R
- KCNH2
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HRH2
- HRH1
- HMGCR
- PDE5A
- PPP3CA
- PRKCA
- TACR1
- UGT2B7
- UGT2B15
- UGT1A9
- UGT1A8
- UGT1A4
- UGT1A3
- UGT1A10
- UGT1A1
- TBXAS1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2D6
- GNAO
- MDR1
- RGS4
- RGS7
- RGS8
Drug classes
- Opioid Antagonists
- Central Nervous System Agents
- Narcotic Antagonists
- Peripheral Nervous System Agents
- Sensory System Agents
- Opioid Antagonist
ATC classes
- A06A · DRUGS FOR CONSTIPATION
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
- OPIOIDS
Cross-references
Synonyms
- BUNAVAIL
- BUPRENORPHINE HYDROCHLORIDE AND NALOXONE HYDROCHLORIDE
- Bunavail
- CASSIPA
- EVZIO
- EVZIO (AUTOINJECTOR)
- KLOXXADO
- Kloxxado
- NALOXONE HYDROCHLORIDE
- NALOXONE HYDROCHLORIDE (AUTOINJECTOR)
- NALOXONE HYDROCHLORIDE AND PENTAZOCINE HYDROCHLORIDE
- naloxone hydrochloride dihydrate
- naloxone hydrochloride hydrate
- naloxone hydrobromide
- evzio
- l-naloxone
- (-)-Naloxone
- naloxone hydrochloride
- naloxone HCl
- Naloxona
- Dbl naloxone
- NSC-70413
- Nalone
- Nalossone
- Naloxonum
- Narcanti
- Narcon
- DBL Naloxone
- Nalossone [DCIT]
- Naloxone HCl
- EN 1530base
- DBL Naloxone (TN)
- L-Naloxone
- N-Allylnoroxymorphone
- Nalone (TN)
- Naloxona [INN-Spanish]
- Naloxone (INN)
Reported adverse events
- NGS
- Addiction
- Hypotension
- Nausea
- Dizziness
- Vomiting
- Depression
- Headache
- Anxiety
- Chills
- Cough
- Dyspepsia
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