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HYDROXYFLUTAMIDE
SynDRA canonical compound SYN0000427 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | AR |
|---|
| Mechanism of action | androgen receptor antagonist |
|---|
All known targets
- AR
- AHR
- CYP2C19
- HTR4
- HTR6
- CYP1A2
- Ar
- Abcb11
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PGR
- CBX1
- CYP3A4
- HDAC6
- HSD17B7
- NFE2L2
- NR3C1
- POLI
- PPARD
- RORC
- SRD5A1
- SRD5A2
- TDP1
- VDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- CP1A2
- CP2C9
- CP2CJ
- CP3A4
- ESR1
- ESRRA
- FXN
- GLI3
- KSYK
- NF2L2
- NR1I2
- PRGR
- SYK
Drug classes
- Androgen Antagonists
- Androgen Receptor Antagonists
- Androgen Receptor Inhibitor
- Antineoplastic Agents
- Antineoplastic Agents, Hormonal
- Hormone Antagonists
ATC classes
- L02B · HORMONE ANTAGONISTS AND RELATED AGENTS
Cross-references
Synonyms
- .alpha.-hydroxyflutamide
- 2-hydroxyflutamide
- Hydroxy-flutamide
- HFT
- Hydroxyniphtholide
- PC1193
- Sch-16423
- OH-flutamide
- Alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide
- Alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide
- 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
- 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- Hydroxy Flutamide
- DTXCID6013562
- RefChem:147185
- ALPHA-HYDROXYFLUTAMIDE
- MFCD00563126
- 2-hydroxy Flutamide
- Liproca Depot
- SMR001227196
- CAS-52806-53-8
- UNII-31D90UKP5Y
- 2ax6
- cid_91649
- MLS001061267
- MLS006011954
- BIDD:ER0519
- GTPL2862
- orb1299590
- SCHEMBL3079778
- SCHEMBL19117358
- SCHEMBL29379312
- BDBM35909
- GLXC-02519
- HMS3039A05
- Hydroxyflutamide, >=98% (HPLC)
- YIA13473
- Tox21_201204
- Tox21_303659
Reported adverse events
- Nausea
- Cystitis
- Proctitis
- Vomiting
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