← SynDRA

LIDOCAINE

SynDRA canonical compound SYN0000422 — structure-anchored drug synonym record

All known targets

• SCN5A
• SCN10A
• SCN9A
• SCN3A
• SCN11A
• SCN2A
• SCN4A
• SCN8A
• SCN1A
• SCN7A
• Scn3a
• Scn2a

Mechanisms of action (all sources)

• Histamine receptor agonist
• SCN1A BLOCKER
• Sodium channel alpha subunit blocker
• SCN5A BLOCKER
• SCN4A BLOCKER
• SCN7A BLOCKER
• SCN2A BLOCKER
• SCN9A BLOCKER
• SCN3A BLOCKER
• SCN11A BLOCKER
• SCN8A BLOCKER
• SCN10A BLOCKER

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ABCB1
• MAPK3
• LCK
• LMNA
• MAOA
• MAOB
• MAPK1
• MAPK14
• MAPT
• NFE2L2
• MC3R
• MC4R
• MC5R
• MDH1
• MLNR
• MMP1
• KCNK18
• KCNH2
• IDH1
• HTR7
• HTR6
• HTR5A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HMGCR
• HDAC6
• GMNN
• GIPR
• MMP9
• NPY1R
• ACHE
• SLCO1B1
• SLC22A1
• SLC29A1
• SLC47A1

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ACM4
• TERA

Drug classes

• Antiarrhythmic
• Anesthetics
• Anesthetics, Local
• Anti-Arrhythmia Agents
• Cardiovascular Agents
• Central Nervous System Agents
• Central Nervous System Depressants
• Membrane Transport Modulators
• Peripheral Nervous System Agents
• Sensory System Agents
• Sodium Channel Blockers
• Voltage-Gated Sodium Channel Blockers

ATC classes

• R02A · THROAT PREPARATIONS
• D04A · ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
• N01B · ANESTHETICS, LOCAL
• S01H · LOCAL ANESTHETICS
• C01B · ANTIARRHYTHMICS, CLASS I AND III
• S02D · OTHER OTOLOGICALS
• C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE

Cross-references

• PubChem CID: 3676
• ChEMBL: CHEMBL79
• DrugBank: DB00281
• ChEBI: CHEBI:6456
• KEGG: D00358
• RxNorm: 6387
• PDB: LQZ
• Wikipedia: Lidocaine
• TTD: D0X4RN
• LINCS BRD: BRD-K52662033

Synonyms

• AKTEN
• ALPHACAINE
• ALPHACAINE HYDROCHLORIDE
• ALPHACAINE HYDROCHLORIDE W/ EPINEPHRINE
• ANESTACON
• Akten
• AneCream
• Aspercreme
• BONDLIDO
• Comfortcaine
• Cutiecaine
• DECADRON W/ XYLOCAINE
• lignocaine
• xylocain
• dalcaine
• duncaine
• esracaine
• solarcaine
• lidocaine hydrochloride
• lidocaine hydrochloride anhydrous
• lidocaine hydrochloride hydrate
• lidocaine HCl
• Lidocaina
• Embolex
• Iontocaine
• Lidocainum
• Octocaine
• Xylestesin
• ALGRX-3268
• NSC-40030
• Alphacaine
• Dentipatch
• Lidocaine component of emla
• Lidocaine component of fortacin
• Lidocaine component of lanabiotic
• Lidocaine component of oraqix
• Lidocaine component of pliaglis
• Lidocaine component of rocephin kit

Reported adverse events

• Hypersensitivity
• Hypersensitivity reaction
• Asthenia
• Bradycardia
• Adverse reaction
• Nausea
• Vomiting
• Tremor
• Vision blurred
• Hypertension
• Chondrolysis
• Injection