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DESIPRAMINE
SynDRA canonical compound SYN0000406 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Tricyclic antidepressant |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A2
- SLC6A4
- ADRA1A
- CHRM1
- HTR2A
- HTR1A
- HRH1
- DRD2
- CHRM5
- CHRM4
- CHRM3
- CHRM2
Mechanisms of action (all sources)
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- SLC29A4 INHIBITOR
- SLC6A4 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- DRD3
- ESR2
- SCN5A
- ABCB1
- PDE4D
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- NPSR1
- NFKB1
- MTOR
- MMP9
- PGR
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- IDH1
- HTT
- HRH3
- PDE5A
- PMP22
- HMGCR
- PPARG
- UGT1A7
- UGT1A4
- UGT1A3
- UGT1A10
- TRPV1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- TPO
- SC6A4
- S29A4
- PLCG1
- LRC26
- KCMB4
- KCMB2
- KCMB1
- KCMA1
- JUN
- IL1B
- IFNG
- GLI3
- CP3A7
- CP3A4
- CP2D6
- CP1A2
- ACM5
- ACM4
- TSHR
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Enzyme Inhibitors
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Tricyclic Antidepressant
ATC classes
Cross-references
Synonyms
- DESIPRAMINE HYDROCHLORIDE
- NORPRAMIN
- Norpramin
- PERTOFRANE
- demethylimipramine
- desimipramine
- desipramin
- desmethylimipramine
- methylaminopropyliminodibenzyl
- monodemethylimipramine
- norimipramine
- desipramine hydrochloride
- desipramine HCl
- Desipramina
- Imipramine, demethyl-
- Monodemethylimipramine
- N-desmethylimipramine
- Norimipramine
- Demethylimipramine
- Desimipramine
- Desimpramine
- Desipramin
- Desipraminum
- Desmethylimipramine
- Dezipramine
- Dimethylimipramine
- Methylaminopropyliminodibenzyl
- Norpramine
- Pentofran
- Pertrofane
- Sertofran
- Desipramine Hcl
- DMI 50475
- DMI (pharmaceutical)
- Desipramina [INN-Spanish]
- Desipramine (D4)
- Desipramine (INN)
- Desipramine [INN:BAN]
Reported adverse events
- Confusional state
- Dry mouth
- Hypotension
- Weight
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