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IRINOTECAN
SynDRA canonical compound SYN0000382 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TOP1 |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | colorectal cancer |
|---|
| Disease area | oncology |
|---|
All known targets
- TOP1
- ABCB1
- ABCC1
- TOP1MT
- SLC47A2
- SLC47A1
- SLC22A3
- SLC22A2
- SLC22A1
- MMP1
- CYP3A5
- CHRM4
Mechanisms of action (all sources)
- topoisomerase inhibitor
- TOP1 INHIBITOR
- DNA topoisomerase I inhibitor
- TOP1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ADORA1
- LCK
- NCOA3
- NCOA1
- MMP9
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- KDM4E
- HDAC6
- KCNH2
- KAT2A
- IDH1
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HSD17B10
- HRH2
- HRH1
- HPGD
- NFE2L2
- NPY1R
- NPY2R
- SIGMAR1
- TDP1
- TBXAS1
- TACR2
- TACR1
- SMN1
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SLC6A4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ACM1
- SYK
- PARP1
- NSD2
- NR5A2
- MDM4
- MDM2
- KSYK
- KLK7
- IFNG
- HCRTR1
- GPX4
- GPX1
- GLI3
- ESRRA
- CSTA
- CASP7
- CASP3
- BRCA1
- BARD1
- ATXN2
- ANDR
- TP53
Drug classes
- Topoisomerase Inhibitors
- Antineoplastic Agents
- Enzyme Inhibitors
- Topoisomerase I Inhibitors
- Topoisomerase Inhibitor
ATC classes
- L01C · PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Cross-references
Synonyms
- CAMPTOSAR
- Camptosar
- IRINOTECAN HYDROCHLORIDE
- ONIVYDE
- Onivyde
- irinotecan liposome injection
- onivyde
- irinotecan liposome
- irinotecan hydrochloride
- irinotecan hydrochloride hydrate
- irinotecan hydrochloride trihydrate
- irinotecan HCl
- Biotecan
- Irinophore c
- NSC-728073
- Irinotecanum
- IRINOTECAN HYDROCHLORIDE Trihydrate
- Irinotecan Hcl
- Irinotecan hydrochloride
- CP0
- Biotecan (TN)
- Campto (TN)
- Camptosar (TN)
- Irinotecan (INN)
- Irinotecan [INN:BAN]
- Irinotecanum [INN-Latin]
- IRINOTECAN, CPT-11
- Camptosar, Campto, CPT-11, Irinotecan
- (+)-Irinotecan
- Irinotecan (TOPO1 inhibitor)
- Irinotecan lactone
- Campto
- Irinophore C
- Irinotecan mylan
- CPT-11
- Irinotecan Free base
- HSDB 7607
- CHEMBL481
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