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THIORIDAZINE
SynDRA canonical compound SYN0000380 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2C |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | psychosis |
|---|
| Disease area | Neurology |
|---|
All known targets
- DRD2
- HTR2A
- HTR2C
- DRD1
- DRD3
- DRD4
- DRD5
- HTR6
- HTR7
- HTR1A
- HRH1
- MALT1
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- D2-like dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
- HTR1A ANTAGONIST
- HTR6 INVERSE AGONIST
- HTR7 INVERSE AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR2
- ADRB2
- ESR1
- CACNA1C
- CASP1
- SCN5A
- MC3R
- MC4R
- OPRM1
- CHRNA4
- MAOA
- OPRD1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- PDE3A
- NPSR1
- PDE4D
- NPC1
- ABCB11
- NFE2L2
- PGR
- MTOR
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- LMNA
- PDE5A
- PPP3CA
- PMP22
- POLI
- USP1
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- NSD2
- KCMB4
- KCNQ1
- KSYK
- M4K2
- MCHR1
- MDM2
- MDM4
- MLLT3
- MMP14
- NLRP1
- NPBW1
- NR1I2
- NTM1A
- 5HT6R
- OXYR
- PPARD
- PPARG
- PPCEL
- PTBP1
- RARA
- SMAD2
- SYK
- TACC3
- TRFR
- TRHR
- TSHR
- KCMB2
- KCMB1
- KCMA1
- JUN
- 5HT7R
- ACES
- ACM1
- ACM4
- ACM5
- ALR
- ANDR
- APAF
Drug classes
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Phenothiazine
ATC classes
Cross-references
Synonyms
- MELLARIL
- MELLARIL-S
- THIORIDAZINE HYDROCHLORIDE
- THIORIDAZINE HYDROCHLORIDE INTENSOL
- thioridazin
- dl-Thioridazine
- malloryl
- meleril
- thioridazine hydrochloride
- thioridazine HCl
- Tioridazina
- Dl-thioridazine
- Mellerette
- Novoridazine
- Sonapax
- Thioridazine prolongatum
- Thioril
- TP-21
- Mellaril-s
- Melleril
- Rideril
- Aldazine
- Mallorol
- Malloryl
- Meleril
- Mellaril
- Mellarit
- Mellerets
- Melleretten
- Melleryl
- Metlaril
- Orsanil
- Ridazine
- Stalleril
- Thioridazin
- Thioridazinum
- Thioxidazine
- Tioridazin
Reported adverse events
- Torsades de pointes
- Agranulocytosis
- Akathisia
- Dyskinesia
- Erythema
- Hepatotoxicity
- Hyperpyrexia
- Hypotension
- Jaundice
- Miosis
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