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DACARBAZINE
SynDRA canonical compound SYN0000373 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PGD | POLA2 |
|---|
| Mechanism of action | DNA alkylating agent |
|---|
| Indication | Hodgkin's lymphoma | melanoma |
|---|
| Disease area | hematologic malignancy | oncology |
|---|
All known targets
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- GMNN
- NPY2R
- NPY1R
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOB
- MAOA
- LMNA
- LCK
- KDM4E
- KCNH2
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH2
- HRH1
- HMGCR
- NR1I2
- NR3C1
- OPRD1
- SLC29A1
- TSHR
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
- SLCO1B3
- SLCO1B1
- SLC6A4
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Alkylating Activity
- Alkylating Drug
- Alkylating Agents
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Noxae
ATC classes
Cross-references
Synonyms
- DTIC-DOME
- deticene
- Dacarbazina
- Biocarbazine r
- Dacarbasine
- Dacarbazinum
- Decarbazine
- Dicarbazine
- DIC
- DTIC
- NCI C04717
- NSC-45388
- Dtic-dome
- Biocarbazin
- Biocarbazine
- DTICDome
- DTIE
- Dacarbazino
- Dacatic
- Deticene
- Dimethyltriazenoimidazolecarboxamide
- ICDMT
- ICDT
- Biocarbazine R
- DTIC-Dome
- Dimethyl Imidazole Carboxamide
- Dimethyl Triazeno Imidazole Carboxamide
- Imidazole carboxamide
- HE1150000
- Carboxamide (TN)
- Carboxamide, Dimethyl Imidazole
- DIC (TN)
- DTIC (TN)
- Dacarbazino [INN-Spanish]
- Dacarbazinum [INN-Latin]
- Imidazole (TN)
- Imidazole Carboxamide, Dimethyl
Reported adverse events
- Hepatic necrosis
- Alopecia
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