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DOFETILIDE
SynDRA canonical compound SYN0000366 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | KCNH2 |
|---|
| Mechanism of action | Potassium channel blocker |
|---|
All known targets
Mechanisms of action (all sources)
- Potassium channel blocker
- KCNH2 BLOCKER
- KCNH1 MODULATOR
- KCNH2 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- AGTR1
- CHRM2
- DRD3
- KCND3
- NR3C1
- NPY2R
- NPY1R
- MLNR
- MC4R
- MC3R
- MAOA
- KDR
- ACHE
- OPRD1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- NTSR1
- OPRK1
- HCAR2
- OPRM1
- TACR1
- SLCO2B1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC47A2
- SLC47A1
- SLC29A1
- SCN5A
- PTGS2
- PTGS1
- PGR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ACM1
- ANDR
- CP3A7
- GCR
- MCL1
Drug classes
- Antiarrhythmic
- Anti-Arrhythmia Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Potassium Channel Blockers
ATC classes
- C01B · ANTIARRHYTHMICS, CLASS I AND III
Cross-references
Synonyms
- DOFETILDE
- TIKOSYN
- Tikosyn
- UK 68798
- tikosyn
- UK-68,798
- Dofetilida
- UK-68798
- Dofetilidum
- Xelide
- Dofetilida [INN-Spanish]
- Dofetilidum [INN-Latin];Tikosyn (TN)
- Dofetilide [USAN:BAN:INN]
- Tikosyn, UK68798, Dofetilide
- Dofetilide (JAN/USAN/INN)
- Beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
- N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide
- N-(4-{2-[methyl(2-{4-[(methylsulfonyl)amino]phenoxy}ethyl)amino]ethyl}phenyl)methanesulfonamide
- Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)
- 1-MSPMPE
- Dofetilidum [INN-Latin]
- UK 68,798
- C19H27N3O5S2
- N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
- Dofetilide (Tikosyn)
- beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide
- CHEMBL473
- R4Z9X1N2ND
- CHEBI:4681
- N-[4-[2-[Methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]methanesulfonamide
- Methanesulfonamide, N-[4-[2-[methyl[2-[4-[(methylsulfonyl)amino]phenoxy]ethyl]amino]ethyl]phenyl]-
- NCGC00164549-01
- UK 68789
- Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)-
- SMR000466333
- Tikosyn (TN)
- CAS-115256-11-6
Reported adverse events
- Arrhythmia
- Ventricular fibrillation
- Ventricular tachycardia
- Bundle branch block
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